Myocardial Infarction Susceptibility and the <i>MTNR1B</i> Polymorphisms
Melatonin is a circadian hormone with antioxidant properties that protects against myocardial ischemia-reperfusion injury. Genetic variations of the melatonin receptor 1B gene (<i>MTNR1B</i>) play an important role in the development of type 2 diabetes, a risk factor for cardiovascular d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/14/11444 |
| Summary: | Melatonin is a circadian hormone with antioxidant properties that protects against myocardial ischemia-reperfusion injury. Genetic variations of the melatonin receptor 1B gene (<i>MTNR1B</i>) play an important role in the development of type 2 diabetes, a risk factor for cardiovascular diseases. Accordingly, <i>MTNR1B</i> polymorphisms are crucial in numerous disorders of the cardiovascular system. Therefore, the aim of the present study was to investigate a possible association of <i>MTNR1B</i> polymorphisms with chronotype and susceptibility to myocardial infarction. The present case-control study included 199 patients with myocardial infarction (MI) (57% men) and 198 control participants (52% men) without previous cardiovascular diseases who underwent genotyping for the <i>MTNR1B</i> polymorphisms rs10830963, rs1387153, and rs4753426 from peripheral blood samples. Chronotype was determined using the Morningness-Eveningness Questionnaire (MEQ). As estimated by the chi-square test, no significant association was found in the distribution of alleles and genotypes between myocardial infarction patients and controls. In addition, there was no association between <i>MTNR1B</i> polymorphisms and chronotype in MI patients. As some previous studies have shown, the present negative results do not exclude the role of the <i>MTNR1B</i> polymorphisms studied in the development of myocardial infarction. Rather, they may indicate that <i>MTNR1B</i> polymorphisms are a minor risk factor for myocardial infarction. |
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| ISSN: | 1661-6596 1422-0067 |