Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature
Pigmented epithelioid melanocytoma (PEM), or animal-type melanoma, is an unusual variant of melanoma which has been reported to have indolent behavior and a relatively good prognosis. We report a 12-year-old girl with PEM on the third finger web of her right hand. Histopathologically, it was compose...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-06-01
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| Series: | Dermatologica Sinica |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1027811711000905 |
| _version_ | 1819266285316341760 |
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| author | Pai-Shan Cheng Shih-Sung Chuang Tseng-Tong Kuo Feng-Jie Lai |
| author_facet | Pai-Shan Cheng Shih-Sung Chuang Tseng-Tong Kuo Feng-Jie Lai |
| author_sort | Pai-Shan Cheng |
| collection | DOAJ |
| description | Pigmented epithelioid melanocytoma (PEM), or animal-type melanoma, is an unusual variant of melanoma which has been reported to have indolent behavior and a relatively good prognosis. We report a 12-year-old girl with PEM on the third finger web of her right hand. Histopathologically, it was composed of heavily pigmented dermal epithelioid and spindled melanocytic tumor cells. A sentinel lymph node biopsy was negative, and no recurrence was noted 1 year later. We reviewed 173 previously published cases of PEM or so-called animal-type melanoma in the literature. Among the 173 cases and our case, extremities were the most common sites of occurrence (52/129, 40.3%), and most of the depth of invasions were Clark level IV and V [76/114 (66.7%) and 33/114 (28.9%), respectively]. Lymph nodes metastasis was noted in 39/89 (43.8%) of the cases being investigated. Only two cases died of the disease with visceral metastasis. Thus, a more advanced level of invasion and the presence of lymph node metastasis did not imply a definitely malignant clinical course, because spreading beyond lymph nodes was rare (5/174, 2.9%). However, long-term follow-up with more cases and further research are needed to fully delineate the true biological nature of this pigmented melanocytic tumor. |
| first_indexed | 2024-12-23T20:58:50Z |
| format | Article |
| id | doaj.art-6c0f5cef308f4c3da19e225c1ee1a3c8 |
| institution | Directory Open Access Journal |
| issn | 1027-8117 |
| language | English |
| last_indexed | 2024-12-23T20:58:50Z |
| publishDate | 2012-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj.art-6c0f5cef308f4c3da19e225c1ee1a3c82022-12-21T17:31:26ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172012-06-01302576110.1016/j.dsi.2011.09.011Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literaturePai-Shan Cheng0Shih-Sung Chuang1Tseng-Tong Kuo2Feng-Jie Lai3Department of Dermatology, Chi Mei Medical Center, Tainan, TaiwanDepartment of Pathology, Chi Mei Medical Center, Tainan and Taipei Medical University, Taipei, TaiwanDepartment of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Dermatology, Chi Mei Medical Center, Tainan, TaiwanPigmented epithelioid melanocytoma (PEM), or animal-type melanoma, is an unusual variant of melanoma which has been reported to have indolent behavior and a relatively good prognosis. We report a 12-year-old girl with PEM on the third finger web of her right hand. Histopathologically, it was composed of heavily pigmented dermal epithelioid and spindled melanocytic tumor cells. A sentinel lymph node biopsy was negative, and no recurrence was noted 1 year later. We reviewed 173 previously published cases of PEM or so-called animal-type melanoma in the literature. Among the 173 cases and our case, extremities were the most common sites of occurrence (52/129, 40.3%), and most of the depth of invasions were Clark level IV and V [76/114 (66.7%) and 33/114 (28.9%), respectively]. Lymph nodes metastasis was noted in 39/89 (43.8%) of the cases being investigated. Only two cases died of the disease with visceral metastasis. Thus, a more advanced level of invasion and the presence of lymph node metastasis did not imply a definitely malignant clinical course, because spreading beyond lymph nodes was rare (5/174, 2.9%). However, long-term follow-up with more cases and further research are needed to fully delineate the true biological nature of this pigmented melanocytic tumor.http://www.sciencedirect.com/science/article/pii/S1027811711000905animal-type melanomacellular blue nevusepithelioid blue nevusmalignant melanomapigmented epithelioid melanocytoma |
| spellingShingle | Pai-Shan Cheng Shih-Sung Chuang Tseng-Tong Kuo Feng-Jie Lai Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature Dermatologica Sinica animal-type melanoma cellular blue nevus epithelioid blue nevus malignant melanoma pigmented epithelioid melanocytoma |
| title | Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature |
| title_full | Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature |
| title_fullStr | Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature |
| title_full_unstemmed | Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature |
| title_short | Pigmented epithelioid melanocytoma: Report of a case and review of 173 cases in the literature |
| title_sort | pigmented epithelioid melanocytoma report of a case and review of 173 cases in the literature |
| topic | animal-type melanoma cellular blue nevus epithelioid blue nevus malignant melanoma pigmented epithelioid melanocytoma |
| url | http://www.sciencedirect.com/science/article/pii/S1027811711000905 |
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