Autotaxin Inhibition with IOA-289 Decreases Breast Tumor Growth in Mice Whereas Knockout of Autotaxin in Adipocytes Does Not

Autotaxin Inhibition with IOA-289 Decreases Breast Tumor Growth in Mice Whereas Knockout of Autotaxin in Adipocytes Does Not

Breast cancer cells produce negligible quantities of autotaxin. Instead, previous work indicated that adipocytes in the inflamed adipose tissue adjacent to breast tumors are a major source of autotaxin secretion that drives breast tumor growth, metastasis, and the loss of efficacy for chemotherapy a...

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Bibliographic Details
Main Authors: Xiaoyun Tang, Andrew J. Morris, Marcel A. Deken, David N. Brindley
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
autotaxin (ATX)
breast tumors
cytokines
CD8α<sup>+</sup>-T cells
inflammation
lysophosphatidic acid (LPA)
Online Access:https://www.mdpi.com/2072-6694/15/11/2937

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https://www.mdpi.com/2072-6694/15/11/2937

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