Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease
Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods. The whole Tc subsets, including T...
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PeerJ Inc.
2016-08-01
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| author | Long Chen Gang Chen Ming-Qiang Zhang Xian-Zhi Xiong Hong-Ju Liu Jian-Bao Xin Jian-Chu Zhang Jiang-Hua Wu Zhao-Ji Meng Sheng-Wen Sun |
| author_facet | Long Chen Gang Chen Ming-Qiang Zhang Xian-Zhi Xiong Hong-Ju Liu Jian-Bao Xin Jian-Chu Zhang Jiang-Hua Wu Zhao-Ji Meng Sheng-Wen Sun |
| author_sort | Long Chen |
| collection | DOAJ |
| description | Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods. The whole Tc subsets, including Tc1/2/10/17, CD8+ regulatory T cells (Tregs) and CD8+α7+ T cells, were quantified by flow cytometry in peripheral blood from 24 stable COPD subjects (SCOPD), 14 patients during acute exacerbations (AECOPD), and 14 healthy nonsmokers (HN). Results. Acute exacerbations of COPD were accompanied by elevated levels of circulating CD8+ T cells. Tc1 cells were increased in both SCOPD and AECOPD patients, whereas the percentage of Tc2 cells was decreased in SCOPD patients but remained normal in AECOPD patients. Tc17 cells were increased only in AECOPD patients, and the percentage of Tc10 cells was reduced in both SCOPD and AECOPD patients. The imbalances of pro/anti-inflammatory Tc subsets observed in COPD may be caused by the lack of Tc10 cells and the impaired anti-inflammatory capacity of CD8+ Tregs. Conclusions. The imbalances between subsets of CD8+ peripheral blood T cells contribute to the immune response dysfunction in COPD pathogenesis. |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:34:12Z |
| publishDate | 2016-08-01 |
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| spelling | doaj.art-6c170b65b19e4f80880cd638b41615602023-12-03T11:01:07ZengPeerJ Inc.PeerJ2167-83592016-08-014e230110.7717/peerj.2301Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary diseaseLong Chen0Gang Chen1Ming-Qiang Zhang2Xian-Zhi Xiong3Hong-Ju Liu4Jian-Bao Xin5Jian-Chu Zhang6Jiang-Hua Wu7Zhao-Ji Meng8Sheng-Wen Sun9Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBackground. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods. The whole Tc subsets, including Tc1/2/10/17, CD8+ regulatory T cells (Tregs) and CD8+α7+ T cells, were quantified by flow cytometry in peripheral blood from 24 stable COPD subjects (SCOPD), 14 patients during acute exacerbations (AECOPD), and 14 healthy nonsmokers (HN). Results. Acute exacerbations of COPD were accompanied by elevated levels of circulating CD8+ T cells. Tc1 cells were increased in both SCOPD and AECOPD patients, whereas the percentage of Tc2 cells was decreased in SCOPD patients but remained normal in AECOPD patients. Tc17 cells were increased only in AECOPD patients, and the percentage of Tc10 cells was reduced in both SCOPD and AECOPD patients. The imbalances of pro/anti-inflammatory Tc subsets observed in COPD may be caused by the lack of Tc10 cells and the impaired anti-inflammatory capacity of CD8+ Tregs. Conclusions. The imbalances between subsets of CD8+ peripheral blood T cells contribute to the immune response dysfunction in COPD pathogenesis.https://peerj.com/articles/2301.pdfCytotoxic T cellsInflammationClinical immunologyRegulatory T cells |
| spellingShingle | Long Chen Gang Chen Ming-Qiang Zhang Xian-Zhi Xiong Hong-Ju Liu Jian-Bao Xin Jian-Chu Zhang Jiang-Hua Wu Zhao-Ji Meng Sheng-Wen Sun Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease PeerJ Cytotoxic T cells Inflammation Clinical immunology Regulatory T cells |
| title | Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease |
| title_full | Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease |
| title_fullStr | Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease |
| title_full_unstemmed | Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease |
| title_short | Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease |
| title_sort | imbalance between subsets of cd8 peripheral blood t cells in patients with chronic obstructive pulmonary disease |
| topic | Cytotoxic T cells Inflammation Clinical immunology Regulatory T cells |
| url | https://peerj.com/articles/2301.pdf |
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