Behavioral and Neuropathological Phenotyping of the Tau58/2 and Tau58/4 Transgenic Mouse Models for FTDP-17

Behavioral and Neuropathological Phenotyping of the Tau58/2 and Tau58/4 Transgenic Mouse Models for FTDP-17

Background: The Tau58/2 and Tau58/4 mouse lines expressing 0N4R tau with a P301S mutation mimic aspects of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). In a side-by-side comparison, we report the age-dependent development of cognitive, motor, and behavioral deficits in...

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Bibliographic Details
Main Authors: Debby Van Dam, Femke Valkenburg, Kristof Van Kolen, Isabel Pintelon, Jean-Pierre Timmermans, Peter Paul De Deyn
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Life
Subjects:
tauopathy
frontotemporal dementia
Alzheimer’s disease
motor dysfunction
cognitive deficits
behavioral disinhibition
Online Access:https://www.mdpi.com/2075-1729/13/10/2088

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