Extending the pool of compatible peptide hydrogels for protein crystallization
Short-peptide supramolecular (SPS) hydrogels are a class of materials that have been found to be useful for (bio)technological applications thanks to their biocompatible nature. Among the advantages reported for these peptides, their economic affordability and easy functionalization or modulation ha...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-05-01
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| Series: | Crystals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4352/9/5/244 |
| _version_ | 1818037408565821440 |
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| author | Guillermo Escolano-Casado Rafael Contreras-Montoya Mayte Conejero-Muriel Albert Castellví Judith Juanhuix Modesto T. Lopez-Lopez Luis Álvarez de Cienfuegos José A. Gavira |
| author_facet | Guillermo Escolano-Casado Rafael Contreras-Montoya Mayte Conejero-Muriel Albert Castellví Judith Juanhuix Modesto T. Lopez-Lopez Luis Álvarez de Cienfuegos José A. Gavira |
| author_sort | Guillermo Escolano-Casado |
| collection | DOAJ |
| description | Short-peptide supramolecular (SPS) hydrogels are a class of materials that have been found to be useful for (bio)technological applications thanks to their biocompatible nature. Among the advantages reported for these peptides, their economic affordability and easy functionalization or modulation have turned them into excellent candidates for the development of functional biomaterials. We have recently demonstrated that SPS hydrogels can be used to produce high-quality protein crystals, improve their properties, or incorporate relevant materials within the crystals. In this work, we prove that hydrogels based on methionine and tyrosine are also good candidates for growing high-quality crystals of the three model proteins: lysozyme, glucose isomerase, and thaumatin. |
| first_indexed | 2024-12-10T07:26:22Z |
| format | Article |
| id | doaj.art-6c1a24c85ffc4d028ba42c4ae19af3b4 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-12-10T07:26:22Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-6c1a24c85ffc4d028ba42c4ae19af3b42022-12-22T01:57:41ZengMDPI AGCrystals2073-43522019-05-019524410.3390/cryst9050244cryst9050244Extending the pool of compatible peptide hydrogels for protein crystallizationGuillermo Escolano-Casado0Rafael Contreras-Montoya1Mayte Conejero-Muriel2Albert Castellví3Judith Juanhuix4Modesto T. Lopez-Lopez5Luis Álvarez de Cienfuegos6José A. Gavira7Laboratorio de Estudios Cristalográficos, Instituto Andaluz de Ciencias de la Tierra (Consejo Superior de Investigaciones Científicas-Universidad de Granada), Avenida de las Palmeras 4, 18100 Armilla, Granada, SpainDepartamento de Química Orgánica, Universidad de Granada, C. U. Fuentenueva, Avda. Severo Ochoa s/n, E-18071 Granada, SpainLaboratorio de Estudios Cristalográficos, Instituto Andaluz de Ciencias de la Tierra (Consejo Superior de Investigaciones Científicas-Universidad de Granada), Avenida de las Palmeras 4, 18100 Armilla, Granada, SpainALBA Synchrotron, Carrer de la Llum 2-26, Cerdanyola del Vallès, 08290 Barcelona, SpainALBA Synchrotron, Carrer de la Llum 2-26, Cerdanyola del Vallès, 08290 Barcelona, SpainDepartamento de Física Aplicada, Facultad de Ciencias, (UGR), SpainDepartamento de Química Orgánica, Universidad de Granada, C. U. Fuentenueva, Avda. Severo Ochoa s/n, E-18071 Granada, SpainLaboratorio de Estudios Cristalográficos, Instituto Andaluz de Ciencias de la Tierra (Consejo Superior de Investigaciones Científicas-Universidad de Granada), Avenida de las Palmeras 4, 18100 Armilla, Granada, SpainShort-peptide supramolecular (SPS) hydrogels are a class of materials that have been found to be useful for (bio)technological applications thanks to their biocompatible nature. Among the advantages reported for these peptides, their economic affordability and easy functionalization or modulation have turned them into excellent candidates for the development of functional biomaterials. We have recently demonstrated that SPS hydrogels can be used to produce high-quality protein crystals, improve their properties, or incorporate relevant materials within the crystals. In this work, we prove that hydrogels based on methionine and tyrosine are also good candidates for growing high-quality crystals of the three model proteins: lysozyme, glucose isomerase, and thaumatin.https://www.mdpi.com/2073-4352/9/5/244protein crystallizationcomposite crystalspeptide hydrogels |
| spellingShingle | Guillermo Escolano-Casado Rafael Contreras-Montoya Mayte Conejero-Muriel Albert Castellví Judith Juanhuix Modesto T. Lopez-Lopez Luis Álvarez de Cienfuegos José A. Gavira Extending the pool of compatible peptide hydrogels for protein crystallization Crystals protein crystallization composite crystals peptide hydrogels |
| title | Extending the pool of compatible peptide hydrogels for protein crystallization |
| title_full | Extending the pool of compatible peptide hydrogels for protein crystallization |
| title_fullStr | Extending the pool of compatible peptide hydrogels for protein crystallization |
| title_full_unstemmed | Extending the pool of compatible peptide hydrogels for protein crystallization |
| title_short | Extending the pool of compatible peptide hydrogels for protein crystallization |
| title_sort | extending the pool of compatible peptide hydrogels for protein crystallization |
| topic | protein crystallization composite crystals peptide hydrogels |
| url | https://www.mdpi.com/2073-4352/9/5/244 |
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