Anti-inflammatory effects of Napoleona imperialis P. Beauv. (Lecythidaceae) on rat model of inflammation
Background: Methanolic extract of Napoleona imperialis, was evaluated for anti-inflammatory effect. Method: Inflammogens used were carrageenan, histamine and formaldehyde. Napoleona imperialis (200-600mg/kg) was administered orally 30 minutes before the induction of inflammation. Diclofenac (10-100...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Health Sciences and Biomedical Research KLEU |
| Subjects: | |
| Online Access: | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=1;spage=89;epage=95;aulast=Ben |
| _version_ | 1818196002970009600 |
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| author | Inemesit Okon Ben Okon Effiom Etim Nsikan Malachy Udo |
| author_facet | Inemesit Okon Ben Okon Effiom Etim Nsikan Malachy Udo |
| author_sort | Inemesit Okon Ben |
| collection | DOAJ |
| description | Background: Methanolic extract of Napoleona imperialis, was evaluated for anti-inflammatory effect.
Method: Inflammogens used were carrageenan, histamine and formaldehyde. Napoleona imperialis (200-600mg/kg) was administered orally 30 minutes before the induction of inflammation. Diclofenac (10-100mg/kg) and chlorpheniramine (10-100 mg/kg) was administered intraperitoneally.
Results: Extract and Diclofenac significantly (F4, 12=15.55, P<0.01; F4, 12=13.76 P<0.01, respectively) inhibited inflammation induced with carrageenan, with extract's maximal inhibitory effect of 64% at dose 400 mg/kg. Diclofenac showed maximal inhibitory effect of 67% at dose 30 mg/kg. Extract and chlorpheniramine significantly (F4, 12=22.14, P<0.01; F4, 12=16.81, P<0.001, respectively) reduced histamine-induced edema with extract having maximal inhibitory effect of 73% at 200 mg/kg. Chlorpheniramine also had maximal inhibitory effect of 70% at 10 mg/kg. Extract and diclofenac significantly (F3, 16=11.06 P<0.001; F3, 16=22.4 P<0.0001, respectively) reduced acute phase of the formaldehyde-induced arthritis. Extract produced maximal effect of 67% at 200 and 400 mg/kg. Diclofenac had a maximal effect of 85% at 100 mg/kg. The chronic phase was ameliorated by extract and diclofenac significantly (F3, 16=11.18 P<0.001; F3, 16=18.07 P<0.0001, respectively). Extract and diclofenac also significantly (F3, 24=19.38 P<0.0001; F3, 24=59.89 P<0.0001, respectively) minimized progression of inflammation from acute to chronic phase. Extract produced a maximal effect of 83% at 400 mg/kg at chronic phase. Diclofenac also had maximal effect of 98% at 30 and 100 mg/kg. Extract and diclofenac, significantly (F4, 12=5.09 P<0.05; F4, 12=31.98 P<0.001, respectively) reduced arthritic score.
Conclusion: This study shows methanolic extracts of Napoleona imperialis leaves have anti-inflammaory effects. |
| first_indexed | 2024-12-12T01:27:10Z |
| format | Article |
| id | doaj.art-6c1a30b3bd1c4a7c8367c65c4d311c1b |
| institution | Directory Open Access Journal |
| issn | 2542-6214 2542-6222 |
| language | English |
| last_indexed | 2024-12-12T01:27:10Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Health Sciences and Biomedical Research KLEU |
| spelling | doaj.art-6c1a30b3bd1c4a7c8367c65c4d311c1b2022-12-22T00:43:04ZengWolters Kluwer Medknow PublicationsIndian Journal of Health Sciences and Biomedical Research KLEU2542-62142542-62222016-01-0191899510.4103/2349-5006.183686Anti-inflammatory effects of Napoleona imperialis P. Beauv. (Lecythidaceae) on rat model of inflammationInemesit Okon BenOkon Effiom EtimNsikan Malachy UdoBackground: Methanolic extract of Napoleona imperialis, was evaluated for anti-inflammatory effect. Method: Inflammogens used were carrageenan, histamine and formaldehyde. Napoleona imperialis (200-600mg/kg) was administered orally 30 minutes before the induction of inflammation. Diclofenac (10-100mg/kg) and chlorpheniramine (10-100 mg/kg) was administered intraperitoneally. Results: Extract and Diclofenac significantly (F4, 12=15.55, P<0.01; F4, 12=13.76 P<0.01, respectively) inhibited inflammation induced with carrageenan, with extract's maximal inhibitory effect of 64% at dose 400 mg/kg. Diclofenac showed maximal inhibitory effect of 67% at dose 30 mg/kg. Extract and chlorpheniramine significantly (F4, 12=22.14, P<0.01; F4, 12=16.81, P<0.001, respectively) reduced histamine-induced edema with extract having maximal inhibitory effect of 73% at 200 mg/kg. Chlorpheniramine also had maximal inhibitory effect of 70% at 10 mg/kg. Extract and diclofenac significantly (F3, 16=11.06 P<0.001; F3, 16=22.4 P<0.0001, respectively) reduced acute phase of the formaldehyde-induced arthritis. Extract produced maximal effect of 67% at 200 and 400 mg/kg. Diclofenac had a maximal effect of 85% at 100 mg/kg. The chronic phase was ameliorated by extract and diclofenac significantly (F3, 16=11.18 P<0.001; F3, 16=18.07 P<0.0001, respectively). Extract and diclofenac also significantly (F3, 24=19.38 P<0.0001; F3, 24=59.89 P<0.0001, respectively) minimized progression of inflammation from acute to chronic phase. Extract produced a maximal effect of 83% at 400 mg/kg at chronic phase. Diclofenac also had maximal effect of 98% at 30 and 100 mg/kg. Extract and diclofenac, significantly (F4, 12=5.09 P<0.05; F4, 12=31.98 P<0.001, respectively) reduced arthritic score. Conclusion: This study shows methanolic extracts of Napoleona imperialis leaves have anti-inflammaory effects.http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=1;spage=89;epage=95;aulast=BenFormaldehydehistaminelambda-carrageenan |
| spellingShingle | Inemesit Okon Ben Okon Effiom Etim Nsikan Malachy Udo Anti-inflammatory effects of Napoleona imperialis P. Beauv. (Lecythidaceae) on rat model of inflammation Indian Journal of Health Sciences and Biomedical Research KLEU Formaldehyde histamine lambda-carrageenan |
| title | Anti-inflammatory effects of Napoleona imperialis P. Beauv. (Lecythidaceae) on rat model of inflammation |
| title_full | Anti-inflammatory effects of Napoleona imperialis P. Beauv. (Lecythidaceae) on rat model of inflammation |
| title_fullStr | Anti-inflammatory effects of Napoleona imperialis P. Beauv. (Lecythidaceae) on rat model of inflammation |
| title_full_unstemmed | Anti-inflammatory effects of Napoleona imperialis P. Beauv. (Lecythidaceae) on rat model of inflammation |
| title_short | Anti-inflammatory effects of Napoleona imperialis P. Beauv. (Lecythidaceae) on rat model of inflammation |
| title_sort | anti inflammatory effects of napoleona imperialis p beauv lecythidaceae on rat model of inflammation |
| topic | Formaldehyde histamine lambda-carrageenan |
| url | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=1;spage=89;epage=95;aulast=Ben |
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