CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS
The aim of the present work was to prepare hydrogel matrix tablets using crosslinked chitosan and hydroxyethyl cellulose (HEC) for controlled release of gabapentin. The chitosan was crosslinked with acetaldehyde and used for the preparation of hydrogel matrix tablets along with hydroxylethyl cellulo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Gadjah Mada
2014-07-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/219 |
| _version_ | 1819051494574391296 |
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| author | Narasimha S. Managoli Raghavendra V. Kulkarni Nadendla Ramarao Iranna S. Muchandi |
| author_facet | Narasimha S. Managoli Raghavendra V. Kulkarni Nadendla Ramarao Iranna S. Muchandi |
| author_sort | Narasimha S. Managoli |
| collection | DOAJ |
| description | The aim of the present work was to prepare hydrogel matrix tablets using crosslinked chitosan and hydroxyethyl cellulose (HEC) for controlled release of gabapentin. The chitosan was crosslinked with acetaldehyde and used for the preparation of hydrogel matrix tablets along with hydroxylethyl cellulose by wet granulation method. The samples were characterized by FTIR, DSC, TGA, XRD, SEM and evaluated drug content, swelling pattern and drug release. The matrix tablets were capable of releasing the drug for 24h depending upon the formulation variables. It was observed that as the concentration of HEC increased in the tablets, the drug release was also increased. On the other hand, as the crosslinking of chitosan was increased, the drug release was decreased. Drug release mechanism followed non-Fickian transport. This study demonstrated that the blend hydrogel matrix tablets of crosslinked chitosan and HEC could be a versatile drug delivery system for controlled release of gabapentin. |
| first_indexed | 2024-12-21T12:04:50Z |
| format | Article |
| id | doaj.art-6c1a35a4cd3b405c93d511a28ca5f06f |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-21T12:04:50Z |
| publishDate | 2014-07-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-6c1a35a4cd3b405c93d511a28ca5f06f2022-12-21T19:04:43ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862014-07-0125316417310.14499/indonesianjpharm25iss3pp164CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETSNarasimha S. Managoli0Raghavendra V. Kulkarni1Nadendla Ramarao2Iranna S. Muchandi3BVVS’s HSK College of Pharmacy, Bagalkot-587101, Karnataka, India.BLDEA’s College of Pharmacy BLDE University Campus, Bijapur-586101, IndiaChalapati Institute of Pharmaceutical Scie, Guntur 522034, Pradesh, IndiaChalapati Institute of PBVVS’s HSK College of Pharmacy, Bagalkot-587101, Karnataka, India.harmaceutical Scie, Guntur 522034, Pradesh, IndiaThe aim of the present work was to prepare hydrogel matrix tablets using crosslinked chitosan and hydroxyethyl cellulose (HEC) for controlled release of gabapentin. The chitosan was crosslinked with acetaldehyde and used for the preparation of hydrogel matrix tablets along with hydroxylethyl cellulose by wet granulation method. The samples were characterized by FTIR, DSC, TGA, XRD, SEM and evaluated drug content, swelling pattern and drug release. The matrix tablets were capable of releasing the drug for 24h depending upon the formulation variables. It was observed that as the concentration of HEC increased in the tablets, the drug release was also increased. On the other hand, as the crosslinking of chitosan was increased, the drug release was decreased. Drug release mechanism followed non-Fickian transport. This study demonstrated that the blend hydrogel matrix tablets of crosslinked chitosan and HEC could be a versatile drug delivery system for controlled release of gabapentin.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/219: tr crosslinked chitosanhydroxyethyl cellulosehydrogel tabletscontrolled releasegabapentin |
| spellingShingle | Narasimha S. Managoli Raghavendra V. Kulkarni Nadendla Ramarao Iranna S. Muchandi CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS Indonesian Journal of Pharmacy : tr crosslinked chitosan hydroxyethyl cellulose hydrogel tablets controlled release gabapentin |
| title | CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS |
| title_full | CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS |
| title_fullStr | CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS |
| title_full_unstemmed | CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS |
| title_short | CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS |
| title_sort | controlled release of gabapentin through reticulated chitosan and hydroxyethyl cellulose hydrogel matrix tablets |
| topic | : tr crosslinked chitosan hydroxyethyl cellulose hydrogel tablets controlled release gabapentin |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/219 |
| work_keys_str_mv | AT narasimhasmanagoli controlledreleaseofgabapentinthroughreticulatedchitosanandhydroxyethylcellulosehydrogelmatrixtablets AT raghavendravkulkarni controlledreleaseofgabapentinthroughreticulatedchitosanandhydroxyethylcellulosehydrogelmatrixtablets AT nadendlaramarao controlledreleaseofgabapentinthroughreticulatedchitosanandhydroxyethylcellulosehydrogelmatrixtablets AT irannasmuchandi controlledreleaseofgabapentinthroughreticulatedchitosanandhydroxyethylcellulosehydrogelmatrixtablets |