Coronary heart disease and the course of newly detected prostate cancer
Introduction. In recent years, the clinical and practical interest in malignant neoplasms and diseases of the cardiovascular system has been extremely high. These nosologies are the leading causes of hospitalisations and deaths worldwide.Objective. To assess the prevalence of coronary heart disease...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2023-10-01
|
| Series: | Vestnik Urologii |
| Subjects: | |
| Online Access: | https://www.urovest.ru/jour/article/view/757 |
| _version_ | 1797272076848988160 |
|---|---|
| author | E. V. Pomeshkin S. V. Popov I. N. Orlov A. I. Bragin-Maltsev S. A. Pomeshkina O. L. Barbarash |
| author_facet | E. V. Pomeshkin S. V. Popov I. N. Orlov A. I. Bragin-Maltsev S. A. Pomeshkina O. L. Barbarash |
| author_sort | E. V. Pomeshkin |
| collection | DOAJ |
| description | Introduction. In recent years, the clinical and practical interest in malignant neoplasms and diseases of the cardiovascular system has been extremely high. These nosologies are the leading causes of hospitalisations and deaths worldwide.Objective. To assess the prevalence of coronary heart disease and risk factors among patients with newly diagnosed prostate cancer, as well as to identify their relationship with the severity of prostate cancer.Materials & methods. The study included 140 newly diagnosed prostate cancer (PCa) patients with a median age of 65 [62; 70] years. All patients had the level of prostate-specific antigen, pelvic MRI, prostate biopsy with determination of Gleason score, all patients filled out the questionnaire of the International Index of Erectile Function (IIEF-5). Depending on the presence of coronary heart disease (CHD), all patients were divided into two groups: Group 1 — 94 (67%) PCa patients without CHD; Group 2 — 46 (33%) PCa patients with CHDResults. In a comparative analysis, the groups did not differ in indicators such as age, BMI, prostate volume, incidence of diabetes mellitus type 2, and lipid status level. However, in PCa patients with CHD, erectile dysfunction was statistically significantly more pronounced than in patients without CHD (10 vs 18 IIEF5 points, p = 0.03), respectively. In terms of PSA levels, it turned out that in Group 2, this indicator was significantly higher than in Group 1 (15.8 ng/ml vs 10.1 ng/ml, p = 0.03), respectively, which indicates possibly more high malignancy of the process. Furthermore, in Group 2, patients with a high grade PCa according to the classification of The International Society of Urological Pathology (ISUP) 4 / 5 were statistically significantly more common compared to patients of Group 1 (12 (26%) vs. 10 (11%), p = 0.01), respectively. In a comparative analysis of patients depending on the risk of a possible PCa recurrence of , which was taken into account by such parameters as PSA level, Gleason index + ISUP grade, it turned out that in Group 2 there were statistically significantly more patients with a higher risk of PCa progression compared to Group 1 (20 (44%) vs 26 (28%), p = 0.02), respectively.Conclusion. PCa patients with concomitant CHD are characterized by a higher waist circumference, they had lower indicators of erectile function, a more pronounced comorbid background, and more often had a history of stroke. In addition, PCa patients with CHD had a high grade PCa and a higher risk of PCa progression. |
| first_indexed | 2024-03-07T14:23:15Z |
| format | Article |
| id | doaj.art-6c1c2618e7be47419d40391bdaad4caa |
| institution | Directory Open Access Journal |
| issn | 2308-6424 |
| language | Russian |
| last_indexed | 2024-03-07T14:23:15Z |
| publishDate | 2023-10-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Vestnik Urologii |
| spelling | doaj.art-6c1c2618e7be47419d40391bdaad4caa2024-03-06T08:56:06ZrusState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationVestnik Urologii2308-64242023-10-01113687610.21886/2308-6424-2023-11-3-68-76467Coronary heart disease and the course of newly detected prostate cancerE. V. Pomeshkin0S. V. Popov1I. N. Orlov2A. I. Bragin-Maltsev3S. A. Pomeshkina4O. L. Barbarash5St. Luke St. Petersburg Clinical Hospital; Kemerovo State UniversitySt. Luke St. Petersburg Clinical HospitalSt. Luke St. Petersburg Clinical HospitalPodgorbunsky Kuzbass Clinical Emergency Hospital; Kemerovo State Medical UniversityFederal State Research Institute for Complex Issues of Cardiovascular DiseasesFederal State Research Institute for Complex Issues of Cardiovascular DiseasesIntroduction. In recent years, the clinical and practical interest in malignant neoplasms and diseases of the cardiovascular system has been extremely high. These nosologies are the leading causes of hospitalisations and deaths worldwide.Objective. To assess the prevalence of coronary heart disease and risk factors among patients with newly diagnosed prostate cancer, as well as to identify their relationship with the severity of prostate cancer.Materials & methods. The study included 140 newly diagnosed prostate cancer (PCa) patients with a median age of 65 [62; 70] years. All patients had the level of prostate-specific antigen, pelvic MRI, prostate biopsy with determination of Gleason score, all patients filled out the questionnaire of the International Index of Erectile Function (IIEF-5). Depending on the presence of coronary heart disease (CHD), all patients were divided into two groups: Group 1 — 94 (67%) PCa patients without CHD; Group 2 — 46 (33%) PCa patients with CHDResults. In a comparative analysis, the groups did not differ in indicators such as age, BMI, prostate volume, incidence of diabetes mellitus type 2, and lipid status level. However, in PCa patients with CHD, erectile dysfunction was statistically significantly more pronounced than in patients without CHD (10 vs 18 IIEF5 points, p = 0.03), respectively. In terms of PSA levels, it turned out that in Group 2, this indicator was significantly higher than in Group 1 (15.8 ng/ml vs 10.1 ng/ml, p = 0.03), respectively, which indicates possibly more high malignancy of the process. Furthermore, in Group 2, patients with a high grade PCa according to the classification of The International Society of Urological Pathology (ISUP) 4 / 5 were statistically significantly more common compared to patients of Group 1 (12 (26%) vs. 10 (11%), p = 0.01), respectively. In a comparative analysis of patients depending on the risk of a possible PCa recurrence of , which was taken into account by such parameters as PSA level, Gleason index + ISUP grade, it turned out that in Group 2 there were statistically significantly more patients with a higher risk of PCa progression compared to Group 1 (20 (44%) vs 26 (28%), p = 0.02), respectively.Conclusion. PCa patients with concomitant CHD are characterized by a higher waist circumference, they had lower indicators of erectile function, a more pronounced comorbid background, and more often had a history of stroke. In addition, PCa patients with CHD had a high grade PCa and a higher risk of PCa progression.https://www.urovest.ru/jour/article/view/757prostate cancerrisk factorscardiac ischemia |
| spellingShingle | E. V. Pomeshkin S. V. Popov I. N. Orlov A. I. Bragin-Maltsev S. A. Pomeshkina O. L. Barbarash Coronary heart disease and the course of newly detected prostate cancer Vestnik Urologii prostate cancer risk factors cardiac ischemia |
| title | Coronary heart disease and the course of newly detected prostate cancer |
| title_full | Coronary heart disease and the course of newly detected prostate cancer |
| title_fullStr | Coronary heart disease and the course of newly detected prostate cancer |
| title_full_unstemmed | Coronary heart disease and the course of newly detected prostate cancer |
| title_short | Coronary heart disease and the course of newly detected prostate cancer |
| title_sort | coronary heart disease and the course of newly detected prostate cancer |
| topic | prostate cancer risk factors cardiac ischemia |
| url | https://www.urovest.ru/jour/article/view/757 |
| work_keys_str_mv | AT evpomeshkin coronaryheartdiseaseandthecourseofnewlydetectedprostatecancer AT svpopov coronaryheartdiseaseandthecourseofnewlydetectedprostatecancer AT inorlov coronaryheartdiseaseandthecourseofnewlydetectedprostatecancer AT aibraginmaltsev coronaryheartdiseaseandthecourseofnewlydetectedprostatecancer AT sapomeshkina coronaryheartdiseaseandthecourseofnewlydetectedprostatecancer AT olbarbarash coronaryheartdiseaseandthecourseofnewlydetectedprostatecancer |