Influence of pH on the release of an active principle from 3D printed carrageenan-k combined with alginate or xanthan gum
The use of 3D printing began to diffuse in the pharmaceutical field in recent times, since 2015, with the approval of the first 3D printed drug from the FDA. The most used materials in association with this technique in this specific scope are hydrogels, already used widely in tissue engineering to...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023040574 |
| _version_ | 1797807049092890624 |
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| author | Dhanalakshmi Vadivel Nicolò Zitarosa Daniele Dondi |
| author_facet | Dhanalakshmi Vadivel Nicolò Zitarosa Daniele Dondi |
| author_sort | Dhanalakshmi Vadivel |
| collection | DOAJ |
| description | The use of 3D printing began to diffuse in the pharmaceutical field in recent times, since 2015, with the approval of the first 3D printed drug from the FDA. The most used materials in association with this technique in this specific scope are hydrogels, already used widely in tissue engineering to produce scaffolds used in the realization of synthetic tissues. The aim of this project was to study the influence of different pH conditions on the release of a therapeutic molecule from a Carrageenan-k combined with alginate or xanthan gum hydrogel with a high level of biocompatibility and enough mechanical resistance to be used as printing material for a 3D bioprinter. The addition of biologically active supplements without affecting the model of the 3D printing structure of the biocompatible polymers was achieved by adopting the extrusion at moderately low temperatures. This study aimed to produce the necessary percentage of hydrogels which is responsible for the release of active drugs which respect to the pH of the system. In this case, the chosen curcumin drug which exhibits active release in the pH of the small intestine is a pH value of 6. |
| first_indexed | 2024-03-13T06:16:41Z |
| format | Article |
| id | doaj.art-6c1d75cc61aa49f99be1fe4d6f668688 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T06:16:41Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6c1d75cc61aa49f99be1fe4d6f6686882023-06-11T04:14:44ZengElsevierHeliyon2405-84402023-06-0196e16850Influence of pH on the release of an active principle from 3D printed carrageenan-k combined with alginate or xanthan gumDhanalakshmi Vadivel0Nicolò Zitarosa1Daniele Dondi2Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy; INFN, Sezione di Pavia, Via Agostino Bassi 6, 27100, Pavia, Italy; Corresponding author. Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100, Pavia, ItalyDepartment of Chemistry, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy; INFN, Sezione di Pavia, Via Agostino Bassi 6, 27100, Pavia, ItalyThe use of 3D printing began to diffuse in the pharmaceutical field in recent times, since 2015, with the approval of the first 3D printed drug from the FDA. The most used materials in association with this technique in this specific scope are hydrogels, already used widely in tissue engineering to produce scaffolds used in the realization of synthetic tissues. The aim of this project was to study the influence of different pH conditions on the release of a therapeutic molecule from a Carrageenan-k combined with alginate or xanthan gum hydrogel with a high level of biocompatibility and enough mechanical resistance to be used as printing material for a 3D bioprinter. The addition of biologically active supplements without affecting the model of the 3D printing structure of the biocompatible polymers was achieved by adopting the extrusion at moderately low temperatures. This study aimed to produce the necessary percentage of hydrogels which is responsible for the release of active drugs which respect to the pH of the system. In this case, the chosen curcumin drug which exhibits active release in the pH of the small intestine is a pH value of 6.http://www.sciencedirect.com/science/article/pii/S24058440230405743D bioprintingpHDrug releaseHydrogelPolymerDye |
| spellingShingle | Dhanalakshmi Vadivel Nicolò Zitarosa Daniele Dondi Influence of pH on the release of an active principle from 3D printed carrageenan-k combined with alginate or xanthan gum Heliyon 3D bioprinting pH Drug release Hydrogel Polymer Dye |
| title | Influence of pH on the release of an active principle from 3D printed carrageenan-k combined with alginate or xanthan gum |
| title_full | Influence of pH on the release of an active principle from 3D printed carrageenan-k combined with alginate or xanthan gum |
| title_fullStr | Influence of pH on the release of an active principle from 3D printed carrageenan-k combined with alginate or xanthan gum |
| title_full_unstemmed | Influence of pH on the release of an active principle from 3D printed carrageenan-k combined with alginate or xanthan gum |
| title_short | Influence of pH on the release of an active principle from 3D printed carrageenan-k combined with alginate or xanthan gum |
| title_sort | influence of ph on the release of an active principle from 3d printed carrageenan k combined with alginate or xanthan gum |
| topic | 3D bioprinting pH Drug release Hydrogel Polymer Dye |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023040574 |
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