Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro
Bufalin (buf) has poor solubility in aqueous solution, poor tumor targeting, and many non-specific toxic and side effects. The advantages of high-molecular-weight polymer conjugates are that they can improve the water solubility of buf, prolong plasma half-life, and reduce non-specific toxicity. A n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/21/4515 |
| _version_ | 1797466743880286208 |
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| author | Jiankun Xu Shanmeng Lin Hao Hu Qi Xing Jin Geng |
| author_facet | Jiankun Xu Shanmeng Lin Hao Hu Qi Xing Jin Geng |
| author_sort | Jiankun Xu |
| collection | DOAJ |
| description | Bufalin (buf) has poor solubility in aqueous solution, poor tumor targeting, and many non-specific toxic and side effects. The advantages of high-molecular-weight polymer conjugates are that they can improve the water solubility of buf, prolong plasma half-life, and reduce non-specific toxicity. A novel water-soluble polymer–drug conjugate with buf and fluorescein pendants was prepared by the combination of reversible addition-fragmentation transfer (RAFT) polymerization and click chemistry. Its anticancer performance and cellular uptake behavior against liver cancer were investigated in vitro. The polymer–buf conjugates exhibit controlled release and tumor-targeting capabilities, showing promise for clinical applications. |
| first_indexed | 2024-03-09T18:43:07Z |
| format | Article |
| id | doaj.art-6c1da0f8542b4b249ec424a7286f22fe |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T18:43:07Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-6c1da0f8542b4b249ec424a7286f22fe2023-11-24T06:27:31ZengMDPI AGPolymers2073-43602022-10-011421451510.3390/polym14214515Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In VitroJiankun Xu0Shanmeng Lin1Hao Hu2Qi Xing3Jin Geng4The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518059, ChinaThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518059, ChinaShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518059, ChinaBufalin (buf) has poor solubility in aqueous solution, poor tumor targeting, and many non-specific toxic and side effects. The advantages of high-molecular-weight polymer conjugates are that they can improve the water solubility of buf, prolong plasma half-life, and reduce non-specific toxicity. A novel water-soluble polymer–drug conjugate with buf and fluorescein pendants was prepared by the combination of reversible addition-fragmentation transfer (RAFT) polymerization and click chemistry. Its anticancer performance and cellular uptake behavior against liver cancer were investigated in vitro. The polymer–buf conjugates exhibit controlled release and tumor-targeting capabilities, showing promise for clinical applications.https://www.mdpi.com/2073-4360/14/21/4515polymer–drug conjugateliver canceresterase responsivebufalin |
| spellingShingle | Jiankun Xu Shanmeng Lin Hao Hu Qi Xing Jin Geng Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro Polymers polymer–drug conjugate liver cancer esterase responsive bufalin |
| title | Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro |
| title_full | Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro |
| title_fullStr | Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro |
| title_full_unstemmed | Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro |
| title_short | Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro |
| title_sort | tumor targeting polymer drug conjugate for liver cancer treatment in vitro |
| topic | polymer–drug conjugate liver cancer esterase responsive bufalin |
| url | https://www.mdpi.com/2073-4360/14/21/4515 |
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