Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation
Bladder neck contracture (BNC) is a complication of the surgical treatment of benign and malignant prostate conditions and is associated with the partial or complete blockage of urination. Correction of this condition usually requires repeated surgical intervention, which does not guarantee recovery...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/10/2186 |
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| author | Olga A. Sindeeva Arkady S. Abdurashitov Pavel I. Proshin Alexey V. Kadrev Oleg A. Kulikov Boris M. Shaparov Nikolay I. Sorokin Valentin P. Ageev Nikolay A. Pyataev Aleksandr Kritskiy Alexander Tishin Armais A. Kamalov Gleb B. Sukhorukov |
| author_facet | Olga A. Sindeeva Arkady S. Abdurashitov Pavel I. Proshin Alexey V. Kadrev Oleg A. Kulikov Boris M. Shaparov Nikolay I. Sorokin Valentin P. Ageev Nikolay A. Pyataev Aleksandr Kritskiy Alexander Tishin Armais A. Kamalov Gleb B. Sukhorukov |
| author_sort | Olga A. Sindeeva |
| collection | DOAJ |
| description | Bladder neck contracture (BNC) is a complication of the surgical treatment of benign and malignant prostate conditions and is associated with the partial or complete blockage of urination. Correction of this condition usually requires repeated surgical intervention, which does not guarantee recovery. Balloon dilation is a minimally invasive alternative to the surgical dissection of tissues; however, it significantly reduces the patient’s quality of life. Additional local anti-inflammatory treatment may reduce the number of procedures requested and increase the attractiveness of this therapeutic strategy. Here, we report about an ultrathin biocompatible coating based on polylactic acid for Foley catheter balloons that can provide localized release of Prednol-L in the range of 56–99 µg in the BNC zone under conventional diagnostic ultrasound exposure. Note that the exposure of a transrectal probe with a conventional gray-scale ultrasound regimen with and without shear wave elastography (SWE) was comparably effective for Prednol-L release from the coating surface of a Foley catheter balloon. This strategy does not require additional manipulations by clinicians. The trigger for the drug release is the ultrasound exposure, which is applied for visualization of the balloon’s location during the dilation process. In vivo experiments demonstrated the absence of negative effects of the usage of a coated Foley catheter for balloon dilation of the bladder neck and urethra. |
| first_indexed | 2024-03-09T19:34:38Z |
| format | Article |
| id | doaj.art-6c1dffbdd6fd43a68b6aa8a1be7f6bb6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:34:38Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-6c1dffbdd6fd43a68b6aa8a1be7f6bb62023-11-24T01:57:47ZengMDPI AGPharmaceutics1999-49232022-10-011410218610.3390/pharmaceutics14102186Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck DilationOlga A. Sindeeva0Arkady S. Abdurashitov1Pavel I. Proshin2Alexey V. Kadrev3Oleg A. Kulikov4Boris M. Shaparov5Nikolay I. Sorokin6Valentin P. Ageev7Nikolay A. Pyataev8Aleksandr Kritskiy9Alexander Tishin10Armais A. Kamalov11Gleb B. Sukhorukov12A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, RussiaA.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, RussiaA.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, RussiaUltrasound Diagnostics Department, Medical Research and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, RussiaInstitute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, RussiaDepartment of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, RussiaDepartment of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, RussiaInstitute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, RussiaInstitute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, RussiaLLC Magnetic Drug Delivery, AMT & C Group, 4 Promyshlennaya Str., Troitsk, 108840 Moscow, RussiaLLC Magnetic Drug Delivery, AMT & C Group, 4 Promyshlennaya Str., Troitsk, 108840 Moscow, RussiaDepartment of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, RussiaA.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, RussiaBladder neck contracture (BNC) is a complication of the surgical treatment of benign and malignant prostate conditions and is associated with the partial or complete blockage of urination. Correction of this condition usually requires repeated surgical intervention, which does not guarantee recovery. Balloon dilation is a minimally invasive alternative to the surgical dissection of tissues; however, it significantly reduces the patient’s quality of life. Additional local anti-inflammatory treatment may reduce the number of procedures requested and increase the attractiveness of this therapeutic strategy. Here, we report about an ultrathin biocompatible coating based on polylactic acid for Foley catheter balloons that can provide localized release of Prednol-L in the range of 56–99 µg in the BNC zone under conventional diagnostic ultrasound exposure. Note that the exposure of a transrectal probe with a conventional gray-scale ultrasound regimen with and without shear wave elastography (SWE) was comparably effective for Prednol-L release from the coating surface of a Foley catheter balloon. This strategy does not require additional manipulations by clinicians. The trigger for the drug release is the ultrasound exposure, which is applied for visualization of the balloon’s location during the dilation process. In vivo experiments demonstrated the absence of negative effects of the usage of a coated Foley catheter for balloon dilation of the bladder neck and urethra.https://www.mdpi.com/1999-4923/14/10/2186ultrasound-induced releaseultrasound-sensitive coatingsPLA coatinglocal drug deliverymicrochamber arraysanti-inflammatory drug |
| spellingShingle | Olga A. Sindeeva Arkady S. Abdurashitov Pavel I. Proshin Alexey V. Kadrev Oleg A. Kulikov Boris M. Shaparov Nikolay I. Sorokin Valentin P. Ageev Nikolay A. Pyataev Aleksandr Kritskiy Alexander Tishin Armais A. Kamalov Gleb B. Sukhorukov Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation Pharmaceutics ultrasound-induced release ultrasound-sensitive coatings PLA coating local drug delivery microchamber arrays anti-inflammatory drug |
| title | Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation |
| title_full | Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation |
| title_fullStr | Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation |
| title_full_unstemmed | Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation |
| title_short | Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation |
| title_sort | ultrasound triggerable coatings for foley catheter balloons for local release of anti inflammatory drugs during bladder neck dilation |
| topic | ultrasound-induced release ultrasound-sensitive coatings PLA coating local drug delivery microchamber arrays anti-inflammatory drug |
| url | https://www.mdpi.com/1999-4923/14/10/2186 |
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