Calcium, Bioenergetics, and Parkinson’s Disease
Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca<sup>2+</sup> oscillations that have been linked to basal mitochondrial oxidant...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/9/2045 |
| Summary: | Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca<sup>2+</sup> oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca<sup>2+</sup> oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress. |
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| ISSN: | 2073-4409 |