Calcium, Bioenergetics, and Parkinson’s Disease
Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca<sup>2+</sup> oscillations that have been linked to basal mitochondrial oxidant...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/9/2045 |
| _version_ | 1797554344417034240 |
|---|---|
| author | Enrico Zampese D. James Surmeier |
| author_facet | Enrico Zampese D. James Surmeier |
| author_sort | Enrico Zampese |
| collection | DOAJ |
| description | Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca<sup>2+</sup> oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca<sup>2+</sup> oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress. |
| first_indexed | 2024-03-10T16:29:39Z |
| format | Article |
| id | doaj.art-6c20c205e29148cdaeacef81e3213284 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T16:29:39Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6c20c205e29148cdaeacef81e32132842023-11-20T12:55:36ZengMDPI AGCells2073-44092020-09-0199204510.3390/cells9092045Calcium, Bioenergetics, and Parkinson’s DiseaseEnrico Zampese0D. James Surmeier1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADegeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson’s disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca<sup>2+</sup> oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca<sup>2+</sup> oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.https://www.mdpi.com/2073-4409/9/9/2045Parkinson’s diseasesubstantia nigradopaminergic neuronsCa<sup>2+</sup>mitochondriabioenergetics |
| spellingShingle | Enrico Zampese D. James Surmeier Calcium, Bioenergetics, and Parkinson’s Disease Cells Parkinson’s disease substantia nigra dopaminergic neurons Ca<sup>2+</sup> mitochondria bioenergetics |
| title | Calcium, Bioenergetics, and Parkinson’s Disease |
| title_full | Calcium, Bioenergetics, and Parkinson’s Disease |
| title_fullStr | Calcium, Bioenergetics, and Parkinson’s Disease |
| title_full_unstemmed | Calcium, Bioenergetics, and Parkinson’s Disease |
| title_short | Calcium, Bioenergetics, and Parkinson’s Disease |
| title_sort | calcium bioenergetics and parkinson s disease |
| topic | Parkinson’s disease substantia nigra dopaminergic neurons Ca<sup>2+</sup> mitochondria bioenergetics |
| url | https://www.mdpi.com/2073-4409/9/9/2045 |
| work_keys_str_mv | AT enricozampese calciumbioenergeticsandparkinsonsdisease AT djamessurmeier calciumbioenergeticsandparkinsonsdisease |