Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility.

Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility.

Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intracellular NAD+ levels are tightly regulated and ofte...

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Main Authors: Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4546114?pdf=render

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