SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5
SERINC5, is a cellular multipass transmembrane protein involved in sphingolipid and phosphatydilserine biogenesis and a known retroviral restriction factor. Here, Timilsina et al. show that SERINC5 is a host restriction factor for SARS-CoV-2 that prevents viral fusion during entry. Further they show...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30609-9 |
| _version_ | 1811324493118832640 |
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| author | Uddhav Timilsina Supawadee Umthong Emily B. Ivey Brandon Waxman Spyridon Stavrou |
| author_facet | Uddhav Timilsina Supawadee Umthong Emily B. Ivey Brandon Waxman Spyridon Stavrou |
| author_sort | Uddhav Timilsina |
| collection | DOAJ |
| description | SERINC5, is a cellular multipass transmembrane protein involved in sphingolipid and phosphatydilserine biogenesis and a known retroviral restriction factor. Here, Timilsina et al. show that SERINC5 is a host restriction factor for SARS-CoV-2 that prevents viral fusion during entry. Further they show that viral ORF7a counteracts SERINC5 anti-viral activity by blocking its incorporation into progeny virions. |
| first_indexed | 2024-04-13T14:15:19Z |
| format | Article |
| id | doaj.art-6c2597e68f2e4a9cbb0f8dad7c3e6670 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T14:15:19Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6c2597e68f2e4a9cbb0f8dad7c3e66702022-12-22T02:43:40ZengNature PortfolioNature Communications2041-17232022-05-0113111510.1038/s41467-022-30609-9SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5Uddhav Timilsina0Supawadee Umthong1Emily B. Ivey2Brandon Waxman3Spyridon Stavrou4Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at BuffaloDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at BuffaloSERINC5, is a cellular multipass transmembrane protein involved in sphingolipid and phosphatydilserine biogenesis and a known retroviral restriction factor. Here, Timilsina et al. show that SERINC5 is a host restriction factor for SARS-CoV-2 that prevents viral fusion during entry. Further they show that viral ORF7a counteracts SERINC5 anti-viral activity by blocking its incorporation into progeny virions.https://doi.org/10.1038/s41467-022-30609-9 |
| spellingShingle | Uddhav Timilsina Supawadee Umthong Emily B. Ivey Brandon Waxman Spyridon Stavrou SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5 Nature Communications |
| title | SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5 |
| title_full | SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5 |
| title_fullStr | SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5 |
| title_full_unstemmed | SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5 |
| title_short | SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5 |
| title_sort | sars cov 2 orf7a potently inhibits the antiviral effect of the host factor serinc5 |
| url | https://doi.org/10.1038/s41467-022-30609-9 |
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