Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction

Tau Acts in Concert With Kinase/Phosphatase Underlying Synaptic Dysfunction

Alzheimer's disease (AD) is characterized by two pathological features: neurofibrillary tangles (NFTs), formed by microtubule-associated protein tau, and abnormal accumulation of amyloid-β (Aβ). Multiple evidence placed synaptic tau as the vital fact of AD pathology, especially at the very earl...

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Bibliographic Details
Main Authors: Xing Fan, Liye Xia, Zheng Zhou, Yanyan Qiu, Chenhao Zhao, Xiaomin Yin, Wei Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
tau
kinase
phosphatase
synaptic dysfunction
Alzheimer's disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.908881/full

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