Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

Transthyretin (TTR) is a homotetrameric protein found in human serum and is implicated in fatal inherited amyloidoses. Destabilization of native TTR confirmation resulting from mutation, environmental changes, and aging causes polymerization and amyloid fibril formation. Although several small molec...

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Bibliographic Details
Main Authors: Amirthalingam Mohankumar, Duraisamy Kalaiselvi, Govindhan Thiruppathi, Sivaramakrishnan Muthusaravanan, Subramaniam Vijayakumar, Rahul Suresh, Shinkichi Tawata, Palanisamy Sundararaj
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
transthyretin
familial amyloid polyneuropathy
santalol isomers
synergism
Caenorhabditis elegans
tetramer stabilizer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.924862/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.924862/full

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