MicroRNAs in T Cell-Immunotherapy
MicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/1/250 |
| _version_ | 1797625688027561984 |
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| author | Sara G. Dosil Ana Rodríguez-Galán Francisco Sánchez-Madrid Lola Fernández-Messina |
| author_facet | Sara G. Dosil Ana Rodríguez-Galán Francisco Sánchez-Madrid Lola Fernández-Messina |
| author_sort | Sara G. Dosil |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies. |
| first_indexed | 2024-03-11T09:59:50Z |
| format | Article |
| id | doaj.art-6c2b4cb928cc4885b23b80799b55b8e6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:59:50Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6c2b4cb928cc4885b23b80799b55b8e62023-11-16T15:30:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124125010.3390/ijms24010250MicroRNAs in T Cell-ImmunotherapySara G. Dosil0Ana Rodríguez-Galán1Francisco Sánchez-Madrid2Lola Fernández-Messina3Immunology Service, Hospital Universitario de la Princesa, Instituto Investigación Sanitaria Princesa, 28006 Madrid, SpainImmunology Service, Hospital Universitario de la Princesa, Instituto Investigación Sanitaria Princesa, 28006 Madrid, SpainImmunology Service, Hospital Universitario de la Princesa, Instituto Investigación Sanitaria Princesa, 28006 Madrid, SpainImmunology Service, Hospital Universitario de la Princesa, Instituto Investigación Sanitaria Princesa, 28006 Madrid, SpainMicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies.https://www.mdpi.com/1422-0067/24/1/250microRNAs (miRNAs)antagomiRNAs (antagomiRs)immunotherapyT cell immunotherapynanoparticles (NPs)nanomedicine |
| spellingShingle | Sara G. Dosil Ana Rodríguez-Galán Francisco Sánchez-Madrid Lola Fernández-Messina MicroRNAs in T Cell-Immunotherapy International Journal of Molecular Sciences microRNAs (miRNAs) antagomiRNAs (antagomiRs) immunotherapy T cell immunotherapy nanoparticles (NPs) nanomedicine |
| title | MicroRNAs in T Cell-Immunotherapy |
| title_full | MicroRNAs in T Cell-Immunotherapy |
| title_fullStr | MicroRNAs in T Cell-Immunotherapy |
| title_full_unstemmed | MicroRNAs in T Cell-Immunotherapy |
| title_short | MicroRNAs in T Cell-Immunotherapy |
| title_sort | micrornas in t cell immunotherapy |
| topic | microRNAs (miRNAs) antagomiRNAs (antagomiRs) immunotherapy T cell immunotherapy nanoparticles (NPs) nanomedicine |
| url | https://www.mdpi.com/1422-0067/24/1/250 |
| work_keys_str_mv | AT saragdosil micrornasintcellimmunotherapy AT anarodriguezgalan micrornasintcellimmunotherapy AT franciscosanchezmadrid micrornasintcellimmunotherapy AT lolafernandezmessina micrornasintcellimmunotherapy |