Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa

Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa

Abstract Background Primaquine (PQ) is recommended as an addition to standard malaria treatments in pre-elimination settings due to its pronounced activity against mature Plasmodium falciparum gametocytes, the parasite stage responsible for onward transmission to mosquitoes. However, PQ may trigger...

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Bibliographic Details
Main Authors: Shehu S. Awandu, Jaishree Raman, Takalani I. Makhanthisa, Philip Kruger, John Frean, Teun Bousema, Jandeli Niemand, Lyn-Marie Birkholtz
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Malaria Journal
Subjects:
Malaria
Primaquine
Malaria elimination
G6PD deficiency
CYP2D6
Online Access:http://link.springer.com/article/10.1186/s12936-018-2271-z

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