Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway

Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway

Abstract Background Docetaxel resistance represents a significant obstacle in the treatment of prostate cancer. The intricate interplay between cytokine signalling pathways and transcriptional control mechanisms in cancer cells contributes to chemotherapeutic resistance, yet the underlying molecular...

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Bibliographic Details
Main Authors: Bisheng Cheng, Lingfeng Li, Tianlong Luo, Qiong Wang, Yong Luo, Shoumin Bai, Kaiwen Li, Yiming Lai, Hai Huang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Single-cell analysis
Prostate cancer
Docetaxel resistance
IL-11
Autocrine signalling
Online Access:https://doi.org/10.1186/s13046-024-02962-8

Internet

https://doi.org/10.1186/s13046-024-02962-8

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