Triptolide in the treatment of systemic lupus erythematosus - regulatory effects on miR-146a in B cell TLR7 signaling pathway in mice

Triptolide in the treatment of systemic lupus erythematosus - regulatory effects on miR-146a in B cell TLR7 signaling pathway in mice

Objective: To clarify the mechanism of triptolide (TP) in alleviating the conditions underlying SLE.Methods: Eight-week-old MRL/lpr mice were randomly divided into a model group (n = 5), low-dose TP (TP-L) group (n = 5), and high-dose TP (TP-H) group (n = 5). Mice in these groups were gavaged with n...

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Bibliographic Details
Main Authors: Yi Zhang, FengQi Zhang, YiNi Gao, MeiJiao Wang, Yan Gao, HaiChang Li, Jing Sun, ChengPing Wen, ZhiJun Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
triptolide
systemic lupus erythematosus
B cell
miR-146a
toll-like receptor 7
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.952775/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.952775/full

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