A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic Ketoacidosis
Juvenile myasthenia gravis (JMG) is an autoimmune disease caused by antibodies affecting the postsynaptic membrane at the neuromuscular junction. The association of JMG with Type I diabetes mellitus (DM), another autoimmune disease, is very rare and the pathogenesis has not been fully explained. Our...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2019-03-01
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| Series: | Journal of Pediatric Research |
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| Online Access: |
http://jpedres.org/archives/archive-detail/article-preview/a-myasthenia-gravis-case-diagnosed-simultaneously-/26279
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| _version_ | 1828031642614104064 |
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| author | Gülin Karacan Küçükali Şakire Başer Mehpare Özkan Şenay Savaş Erdeve Zehra Aycan |
| author_facet | Gülin Karacan Küçükali Şakire Başer Mehpare Özkan Şenay Savaş Erdeve Zehra Aycan |
| author_sort | Gülin Karacan Küçükali |
| collection | DOAJ |
| description | Juvenile myasthenia gravis (JMG) is an autoimmune disease caused by antibodies affecting the postsynaptic membrane at the neuromuscular junction. The association of JMG with Type I diabetes mellitus (DM), another autoimmune disease, is very rare and the pathogenesis has not been fully explained. Our case is the youngest patient where this association has been reported in the literature and presented at the age of 4 years when diabetic ketoacidosis developed together with the emergence of ocular myasthenia findings. She is the only case diagnosed with JMG among the 510 Type I DM patients followed-up at our clinic. Although an autoimmune process may have triggered both autoimmune diseases at the same time in this case, we believe the diabetic ketoacidosis was a triggering factor for the JMG and discuss this association. |
| first_indexed | 2024-04-10T14:52:11Z |
| format | Article |
| id | doaj.art-6c2e659ba44f4fb78d3810dd2414ed08 |
| institution | Directory Open Access Journal |
| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T14:52:11Z |
| publishDate | 2019-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-6c2e659ba44f4fb78d3810dd2414ed082023-02-15T16:07:34ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782019-03-0161737610.4274/jpr.galenos.2018.2656613049054A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic KetoacidosisGülin Karacan Küçükali0Şakire Başer1Mehpare Özkan2Şenay Savaş Erdeve3Zehra Aycan4 Ankara Dr. Sami Ulus Obstetrics and Gynecology Children’s Health and Disease Training and Research Hospital, Clinic of Pediatric Endocrinology, Ankara, Turkey Ankara Dr. Sami Ulus Obstetrics and Gynecology Children’s Health and Disease Training and Research Hospital, Clinic of Pediatrics, Ankara, Turkey Ankara Dr. Sami Ulus Obstetrics and Gynecology Children’s Health and Disease Training and Research Hospital, Clinic of Pediatric Neurology, Ankara, Turkey Ankara Dr. Sami Ulus Obstetrics and Gynecology Children’s Health and Disease Training and Research Hospital, Clinic of Pediatric Endocrinology, Ankara, Turkey Ankara Dr. Sami Ulus Obstetrics and Gynecology Children’s Health and Disease Training and Research Hospital, Clinic of Pediatric Endocrinology, Ankara, Turkey Juvenile myasthenia gravis (JMG) is an autoimmune disease caused by antibodies affecting the postsynaptic membrane at the neuromuscular junction. The association of JMG with Type I diabetes mellitus (DM), another autoimmune disease, is very rare and the pathogenesis has not been fully explained. Our case is the youngest patient where this association has been reported in the literature and presented at the age of 4 years when diabetic ketoacidosis developed together with the emergence of ocular myasthenia findings. She is the only case diagnosed with JMG among the 510 Type I DM patients followed-up at our clinic. Although an autoimmune process may have triggered both autoimmune diseases at the same time in this case, we believe the diabetic ketoacidosis was a triggering factor for the JMG and discuss this association. http://jpedres.org/archives/archive-detail/article-preview/a-myasthenia-gravis-case-diagnosed-simultaneously-/26279 Type I diabetes mellitusdiabetic ketoacidosisjuvenile myasthenia gravis |
| spellingShingle | Gülin Karacan Küçükali Şakire Başer Mehpare Özkan Şenay Savaş Erdeve Zehra Aycan A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic Ketoacidosis Journal of Pediatric Research Type I diabetes mellitus diabetic ketoacidosis juvenile myasthenia gravis |
| title | A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic Ketoacidosis |
| title_full | A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic Ketoacidosis |
| title_fullStr | A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic Ketoacidosis |
| title_full_unstemmed | A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic Ketoacidosis |
| title_short | A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic Ketoacidosis |
| title_sort | myasthenia gravis case diagnosed simultaneously with diabetic ketoacidosis |
| topic | Type I diabetes mellitus diabetic ketoacidosis juvenile myasthenia gravis |
| url |
http://jpedres.org/archives/archive-detail/article-preview/a-myasthenia-gravis-case-diagnosed-simultaneously-/26279
|
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