Uptake, acceptability and interpretability of 3‐in‐1 rapid blood self‐testing for HIV, hepatitis B and hepatitis C
Abstract Introduction Early diagnosis is key to achieving the goal of eliminating transmission of HIV and hepatitis B and C. We assessed the uptake, acceptability and interpretability of self‐testing using a 3‐in‐1 rapid diagnostic test (RDT) in facility‐based services. Methods Stand‐alone testing s...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
|
| Series: | Journal of the International AIDS Society |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jia2.26053 |
| _version_ | 1797976230868287488 |
|---|---|
| author | Nicolas Salvadori Jullapong Achalapong Chonlatorn Boontan Choosakun Piriya Surachet Arunothong Sawitree Nangola Chiraphat Kloypan Eakkapote Prompunt Woottichai Khamduang Phornphimon Moolnoi Sakorn Pornprasert Sumet Ongwandee Jean Yves Mary Gonzague Jourdain Nicole Ngo‐Giang‐Huong |
| author_facet | Nicolas Salvadori Jullapong Achalapong Chonlatorn Boontan Choosakun Piriya Surachet Arunothong Sawitree Nangola Chiraphat Kloypan Eakkapote Prompunt Woottichai Khamduang Phornphimon Moolnoi Sakorn Pornprasert Sumet Ongwandee Jean Yves Mary Gonzague Jourdain Nicole Ngo‐Giang‐Huong |
| author_sort | Nicolas Salvadori |
| collection | DOAJ |
| description | Abstract Introduction Early diagnosis is key to achieving the goal of eliminating transmission of HIV and hepatitis B and C. We assessed the uptake, acceptability and interpretability of self‐testing using a 3‐in‐1 rapid diagnostic test (RDT) in facility‐based services. Methods Stand‐alone testing services were provided free of charge to consenting individuals aged ≥15 years in five facilities in northern Thailand. Clients were invited to choose between self‐testing by fingerprick or venepuncture by a healthcare worker (HCW). In each facility, several clients could simultaneously self‐test in separate private areas using TriQuik™ (Genlantis, San Diego, CA, USA), a single immunochromatographic cassette detecting HIV‐1/2 antibody, hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCAb). An interactive program on a tablet computer was developed to collect socio‐demographic, behavioural and satisfaction data and provide information to guide the self‐test process, including video instructions, results interpretation and a picture of the cassette for immediate remote review by the HCW. When the HCW interpreted an HIV self‐test as positive, the HCW collected blood by venepuncture for immediate confirmation. Results Between October 2020 and April 2022, 4119 clients presented for testing for the first time as part of the project. Of them, 3462 (84.0%) opted for self‐testing. Among self‐testers, 1801 (52.0%) were born female, the median age was 27 years (interquartile range, 22–36), 661 (19.1%) belonged to at least one key population and 2124 (61.4%) had never been tested for HIV; 3329 (99.8% of those who answered) reported being “very satisfied” or “satisfied” with the testing process. The proportions of test results interpreted as positive by self‐testers among those interpreted as positive by HCWs were 95% for HIV‐1/2 antibody, 95% for HBsAg and 78% for HCAb. Conclusions These proportions were higher than those observed in a previous study evaluating another 3‐in‐1 RDT for HIV, HBsAg and HCAb, possibly due to the use of video instructions instead of paper‐based instructions, lower prevalence and co‐infection rates, or lower percentages of clients with low education level. Multiplex self‐testing simplified and streamlined the service delivery process and was well accepted. HCW assistance proved to be essential in a limited number of cases. |
| first_indexed | 2024-04-11T04:47:47Z |
| format | Article |
| id | doaj.art-6c2f4fc14c584e26bb8b92e99772c43e |
| institution | Directory Open Access Journal |
| issn | 1758-2652 |
| language | English |
| last_indexed | 2024-04-11T04:47:47Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the International AIDS Society |
| spelling | doaj.art-6c2f4fc14c584e26bb8b92e99772c43e2022-12-27T08:56:30ZengWileyJournal of the International AIDS Society1758-26522022-12-012512n/an/a10.1002/jia2.26053Uptake, acceptability and interpretability of 3‐in‐1 rapid blood self‐testing for HIV, hepatitis B and hepatitis CNicolas Salvadori0Jullapong Achalapong1Chonlatorn Boontan2Choosakun Piriya3Surachet Arunothong4Sawitree Nangola5Chiraphat Kloypan6Eakkapote Prompunt7Woottichai Khamduang8Phornphimon Moolnoi9Sakorn Pornprasert10Sumet Ongwandee11Jean Yves Mary12Gonzague Jourdain13Nicole Ngo‐Giang‐Huong14Thailand‐France Research Collaboration, Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai ThailandChiangrai Prachanukroh Hospital Chiang Rai ThailandOffice of Disease Prevention and Control Region 1 Chiang Mai Department of Disease Control Ministry of Public Health Chiang Mai ThailandOffice of Disease Prevention and Control Region 1 Chiang Mai Department of Disease Control Ministry of Public Health Chiang Mai ThailandOffice of Disease Prevention and Control Region 1 Chiang Mai Department of Disease Control Ministry of Public Health Chiang Mai ThailandDivision of Clinical Immunology and Transfusion Sciences Department of Medical Technology School of Allied Health Sciences University of Phayao Phayao ThailandDepartment of Pathology, School of Medicine University of Phayao Phayao ThailandDivision of Clinical Microbiology, Department of Medical Technology School of Allied Health Sciences University of Phayao Phayao ThailandThailand‐France Research Collaboration, Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai ThailandThailand‐France Research Collaboration, Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai ThailandDepartment of Medical Technology Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai ThailandOffice of Disease Prevention and Control Region 1 Chiang Mai Department of Disease Control Ministry of Public Health Chiang Mai ThailandINSERM U1153, Team ECSTRRA Université Paris Cité, Hôpital Saint‐Louis Paris FranceThailand‐France Research Collaboration, Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai ThailandThailand‐France Research Collaboration, Faculty of Associated Medical Sciences Chiang Mai University Chiang Mai ThailandAbstract Introduction Early diagnosis is key to achieving the goal of eliminating transmission of HIV and hepatitis B and C. We assessed the uptake, acceptability and interpretability of self‐testing using a 3‐in‐1 rapid diagnostic test (RDT) in facility‐based services. Methods Stand‐alone testing services were provided free of charge to consenting individuals aged ≥15 years in five facilities in northern Thailand. Clients were invited to choose between self‐testing by fingerprick or venepuncture by a healthcare worker (HCW). In each facility, several clients could simultaneously self‐test in separate private areas using TriQuik™ (Genlantis, San Diego, CA, USA), a single immunochromatographic cassette detecting HIV‐1/2 antibody, hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCAb). An interactive program on a tablet computer was developed to collect socio‐demographic, behavioural and satisfaction data and provide information to guide the self‐test process, including video instructions, results interpretation and a picture of the cassette for immediate remote review by the HCW. When the HCW interpreted an HIV self‐test as positive, the HCW collected blood by venepuncture for immediate confirmation. Results Between October 2020 and April 2022, 4119 clients presented for testing for the first time as part of the project. Of them, 3462 (84.0%) opted for self‐testing. Among self‐testers, 1801 (52.0%) were born female, the median age was 27 years (interquartile range, 22–36), 661 (19.1%) belonged to at least one key population and 2124 (61.4%) had never been tested for HIV; 3329 (99.8% of those who answered) reported being “very satisfied” or “satisfied” with the testing process. The proportions of test results interpreted as positive by self‐testers among those interpreted as positive by HCWs were 95% for HIV‐1/2 antibody, 95% for HBsAg and 78% for HCAb. Conclusions These proportions were higher than those observed in a previous study evaluating another 3‐in‐1 RDT for HIV, HBsAg and HCAb, possibly due to the use of video instructions instead of paper‐based instructions, lower prevalence and co‐infection rates, or lower percentages of clients with low education level. Multiplex self‐testing simplified and streamlined the service delivery process and was well accepted. HCW assistance proved to be essential in a limited number of cases.https://doi.org/10.1002/jia2.26053hepatitis Bhepatitis CHIVpoint‐of‐care testingrapid diagnostic testself‐testing |
| spellingShingle | Nicolas Salvadori Jullapong Achalapong Chonlatorn Boontan Choosakun Piriya Surachet Arunothong Sawitree Nangola Chiraphat Kloypan Eakkapote Prompunt Woottichai Khamduang Phornphimon Moolnoi Sakorn Pornprasert Sumet Ongwandee Jean Yves Mary Gonzague Jourdain Nicole Ngo‐Giang‐Huong Uptake, acceptability and interpretability of 3‐in‐1 rapid blood self‐testing for HIV, hepatitis B and hepatitis C Journal of the International AIDS Society hepatitis B hepatitis C HIV point‐of‐care testing rapid diagnostic test self‐testing |
| title | Uptake, acceptability and interpretability of 3‐in‐1 rapid blood self‐testing for HIV, hepatitis B and hepatitis C |
| title_full | Uptake, acceptability and interpretability of 3‐in‐1 rapid blood self‐testing for HIV, hepatitis B and hepatitis C |
| title_fullStr | Uptake, acceptability and interpretability of 3‐in‐1 rapid blood self‐testing for HIV, hepatitis B and hepatitis C |
| title_full_unstemmed | Uptake, acceptability and interpretability of 3‐in‐1 rapid blood self‐testing for HIV, hepatitis B and hepatitis C |
| title_short | Uptake, acceptability and interpretability of 3‐in‐1 rapid blood self‐testing for HIV, hepatitis B and hepatitis C |
| title_sort | uptake acceptability and interpretability of 3 in 1 rapid blood self testing for hiv hepatitis b and hepatitis c |
| topic | hepatitis B hepatitis C HIV point‐of‐care testing rapid diagnostic test self‐testing |
| url | https://doi.org/10.1002/jia2.26053 |
| work_keys_str_mv | AT nicolassalvadori uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT jullapongachalapong uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT chonlatornboontan uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT choosakunpiriya uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT surachetarunothong uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT sawitreenangola uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT chiraphatkloypan uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT eakkapoteprompunt uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT woottichaikhamduang uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT phornphimonmoolnoi uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT sakornpornprasert uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT sumetongwandee uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT jeanyvesmary uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT gonzaguejourdain uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc AT nicolengogianghuong uptakeacceptabilityandinterpretabilityof3in1rapidbloodselftestingforhivhepatitisbandhepatitisc |