Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glands
Abstract Objective We investigated the factors affecting postoperative parathyroid gland (PTG) function and devised an objective index to predict the postoperative PTG function during total thyroidectomy. Method This was a retrospective clinical review of 21 consecutive patients who were diagnosed w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.868 |
| _version_ | 1798042193676468224 |
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| author | Keisuke Iritani Masanori Teshima Hikari Shimoda Hirotaka Shinomiya Naoki Otsuki Ken‐ichi Nibu |
| author_facet | Keisuke Iritani Masanori Teshima Hikari Shimoda Hirotaka Shinomiya Naoki Otsuki Ken‐ichi Nibu |
| author_sort | Keisuke Iritani |
| collection | DOAJ |
| description | Abstract Objective We investigated the factors affecting postoperative parathyroid gland (PTG) function and devised an objective index to predict the postoperative PTG function during total thyroidectomy. Method This was a retrospective clinical review of 21 consecutive patients who were diagnosed with papillary thyroid carcinoma and underwent total thyroidectomy. The maximum intensity ratio (MIR) was determined as the maximum fluorescence intensity after ICG injection divided by the intensity before ICG injection. Results Postoperative hypoparathyroidism is significantly associated with simultaneous central neck dissection (CND) and lateral neck dissection (LND) (p = .032). The Spearman correlation test showed a moderate correlation between the MIR and iPTH levels (p = .0047). The optimal MIR cutoff value for predicting postoperative hypoparathyroidism was 2.14 with area under the curve = 0.904 (sensitivity: 0.769 and specificity: 1.00). Conclusion CND + LND was significantly associated with postoperative hypoparathyroidism. MIR was found useful in predicting the postoperative PTG function. Level of Evidence: 3b. |
| first_indexed | 2024-04-11T22:32:04Z |
| format | Article |
| id | doaj.art-6c2f7ecd455344248ba0ca65f892cfbc |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-04-11T22:32:04Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-6c2f7ecd455344248ba0ca65f892cfbc2022-12-22T03:59:20ZengWileyLaryngoscope Investigative Otolaryngology2378-80382022-08-01741251125810.1002/lio2.868Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glandsKeisuke Iritani0Masanori Teshima1Hikari Shimoda2Hirotaka Shinomiya3Naoki Otsuki4Ken‐ichi Nibu5Department of Otolaryngology‐Head and Neck Surgery Kobe University Graduate School of Medicine Kobe JapanDepartment of Otolaryngology‐Head and Neck Surgery Kobe University Graduate School of Medicine Kobe JapanDepartment of Otolaryngology‐Head and Neck Surgery Kobe University Graduate School of Medicine Kobe JapanDepartment of Otolaryngology‐Head and Neck Surgery Kobe University Graduate School of Medicine Kobe JapanDepartment of Otolaryngology‐Head and Neck Surgery Kobe University Graduate School of Medicine Kobe JapanDepartment of Otolaryngology‐Head and Neck Surgery Kobe University Graduate School of Medicine Kobe JapanAbstract Objective We investigated the factors affecting postoperative parathyroid gland (PTG) function and devised an objective index to predict the postoperative PTG function during total thyroidectomy. Method This was a retrospective clinical review of 21 consecutive patients who were diagnosed with papillary thyroid carcinoma and underwent total thyroidectomy. The maximum intensity ratio (MIR) was determined as the maximum fluorescence intensity after ICG injection divided by the intensity before ICG injection. Results Postoperative hypoparathyroidism is significantly associated with simultaneous central neck dissection (CND) and lateral neck dissection (LND) (p = .032). The Spearman correlation test showed a moderate correlation between the MIR and iPTH levels (p = .0047). The optimal MIR cutoff value for predicting postoperative hypoparathyroidism was 2.14 with area under the curve = 0.904 (sensitivity: 0.769 and specificity: 1.00). Conclusion CND + LND was significantly associated with postoperative hypoparathyroidism. MIR was found useful in predicting the postoperative PTG function. Level of Evidence: 3b.https://doi.org/10.1002/lio2.868autofluorescenceindocyanine greennear‐infraredparathyroid glandthyroidectomy |
| spellingShingle | Keisuke Iritani Masanori Teshima Hikari Shimoda Hirotaka Shinomiya Naoki Otsuki Ken‐ichi Nibu Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glands Laryngoscope Investigative Otolaryngology autofluorescence indocyanine green near‐infrared parathyroid gland thyroidectomy |
| title | Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glands |
| title_full | Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glands |
| title_fullStr | Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glands |
| title_full_unstemmed | Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glands |
| title_short | Intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging ‐ surgical strategies for preserving the function of parathyroid glands |
| title_sort | intraoperative quantitative assessment of parathyroid blood flow during total thyroidectomy using indocyanine green fluorescence imaging surgical strategies for preserving the function of parathyroid glands |
| topic | autofluorescence indocyanine green near‐infrared parathyroid gland thyroidectomy |
| url | https://doi.org/10.1002/lio2.868 |
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