Chemogenetic and optogenetic stimulation of zona incerta GABAergic neurons ameliorates motor impairment in Parkinson’s disease

Chemogenetic and optogenetic stimulation of zona incerta GABAergic neurons ameliorates motor impairment in Parkinson’s disease

Summary: Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra and leads to progressive motor dysfunction. While studies have focused on the basal ganglia network, recent evidence suggests neuronal systems outside the basal ganglia are also rel...

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Bibliographic Details
Main Authors: Fenghua Chen, Junliang Qian, Zhongkai Cao, Ang Li, Juntao Cui, Limin Shi, Junxia Xie
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Behavioral neuroscience
Cellular neuroscience
Sensory neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223012269

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