Collagen/silica nanocomposites and hybrids for bone tissue engineering
Collagen is increasingly attracting attention for bone tissue engineering applications. However, due to its low mechanical properties, applications including mechanical loads or requiring structural integrity are limited. To tackle this handicap, collagen can be combined with (nanoscale) silica in a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2013-08-01
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| Series: | Nanotechnology Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/ntrev-2013-0012 |
| _version_ | 1818362551502635008 |
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| author | Sarker Bapi Lyer Stefan Arkudas Andreas Boccaccini Aldo R. |
| author_facet | Sarker Bapi Lyer Stefan Arkudas Andreas Boccaccini Aldo R. |
| author_sort | Sarker Bapi |
| collection | DOAJ |
| description | Collagen is increasingly attracting attention for bone tissue engineering applications. However, due to its low mechanical properties, applications including mechanical loads or requiring structural integrity are limited. To tackle this handicap, collagen can be combined with (nanoscale) silica in a variety of composite materials that are attractive for bone tissue engineering. Considering research carried out in the past 15 years, this article reviews the literature discussing the development of silica/collagen composites that have been synthesized by adding silica from different sources as inorganic bioactive material to collagen as organic matrix. Different routes for the fabrication of collagen/silica composites are presented, focusing on nanocomposites. In vitro cell bioactivity studies demonstrated the osteogenic and, in some cases, angiogenic potential of the composites. Relevant in vivo studies discussing integration of the materials in bone tissue are discussed. Due to the understanding of possible interaction between silicon species and collagen, the effect of different silica precursors on the collagen self-assembly process is also discussed. On the basis of literature results and as discussed in this review, collagen/silica nanocomposites and hybrids represent attractive biomaterials for bone regeneration applications. |
| first_indexed | 2024-12-13T21:34:23Z |
| format | Article |
| id | doaj.art-6c32bf8cd5284dea9ef94d9e965cc761 |
| institution | Directory Open Access Journal |
| issn | 2191-9089 2191-9097 |
| language | English |
| last_indexed | 2024-12-13T21:34:23Z |
| publishDate | 2013-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanotechnology Reviews |
| spelling | doaj.art-6c32bf8cd5284dea9ef94d9e965cc7612022-12-21T23:30:43ZengDe GruyterNanotechnology Reviews2191-90892191-90972013-08-012442744710.1515/ntrev-2013-0012Collagen/silica nanocomposites and hybrids for bone tissue engineeringSarker Bapi0Lyer Stefan1Arkudas Andreas2Boccaccini Aldo R.3Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Section for Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, University Hospital Erlangen, Erlangen, GermanyDepartment of Plastic and Hand Surgery, University of Erlangen Medical Center, Krankenhausstrasse 12, 91054 Erlangen, GermanyInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, GermanyCollagen is increasingly attracting attention for bone tissue engineering applications. However, due to its low mechanical properties, applications including mechanical loads or requiring structural integrity are limited. To tackle this handicap, collagen can be combined with (nanoscale) silica in a variety of composite materials that are attractive for bone tissue engineering. Considering research carried out in the past 15 years, this article reviews the literature discussing the development of silica/collagen composites that have been synthesized by adding silica from different sources as inorganic bioactive material to collagen as organic matrix. Different routes for the fabrication of collagen/silica composites are presented, focusing on nanocomposites. In vitro cell bioactivity studies demonstrated the osteogenic and, in some cases, angiogenic potential of the composites. Relevant in vivo studies discussing integration of the materials in bone tissue are discussed. Due to the understanding of possible interaction between silicon species and collagen, the effect of different silica precursors on the collagen self-assembly process is also discussed. On the basis of literature results and as discussed in this review, collagen/silica nanocomposites and hybrids represent attractive biomaterials for bone regeneration applications.https://doi.org/10.1515/ntrev-2013-0012bioactivitycollagennanocompositeosteogenesissilica |
| spellingShingle | Sarker Bapi Lyer Stefan Arkudas Andreas Boccaccini Aldo R. Collagen/silica nanocomposites and hybrids for bone tissue engineering Nanotechnology Reviews bioactivity collagen nanocomposite osteogenesis silica |
| title | Collagen/silica nanocomposites and hybrids for bone tissue engineering |
| title_full | Collagen/silica nanocomposites and hybrids for bone tissue engineering |
| title_fullStr | Collagen/silica nanocomposites and hybrids for bone tissue engineering |
| title_full_unstemmed | Collagen/silica nanocomposites and hybrids for bone tissue engineering |
| title_short | Collagen/silica nanocomposites and hybrids for bone tissue engineering |
| title_sort | collagen silica nanocomposites and hybrids for bone tissue engineering |
| topic | bioactivity collagen nanocomposite osteogenesis silica |
| url | https://doi.org/10.1515/ntrev-2013-0012 |
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