Computational biomechanical and biodegradation integrity assessment of Mg-based biomedical devices for cardiovascular and orthopedic applications: A review
Magnesium and magnesium based alloys biomaterials are considered the most viable and pragmatic choice of selection as biomedical alternatives for tissue repair of damaged bones, vascular and other biological disorders. Considering the sensitivity and health implication of implanting foreign matter i...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-06-01
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| Series: | International Journal of Lightweight Materials and Manufacture |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2588840422000063 |
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| author | Kenneth Kanayo Alaneme Sodiq Abiodun Kareem Jimmy L. Olajide Rotimi Emmanual Sadiku Michael Oluwatosin Bodunrin |
| author_facet | Kenneth Kanayo Alaneme Sodiq Abiodun Kareem Jimmy L. Olajide Rotimi Emmanual Sadiku Michael Oluwatosin Bodunrin |
| author_sort | Kenneth Kanayo Alaneme |
| collection | DOAJ |
| description | Magnesium and magnesium based alloys biomaterials are considered the most viable and pragmatic choice of selection as biomedical alternatives for tissue repair of damaged bones, vascular and other biological disorders. Considering the sensitivity and health implication of implanting foreign matter into the human system, extensive studies are required before clearance for clinical trials is given. This often requires rigorous experimental evaluations of biomechanical and biodegradation properties of such biomaterials, which are often expensive, time consuming and practically demanding, and requires several validation protocols. The technical advances in computing power as well as computational modeling techniques, such as finite element analysis, have been sort to address these limitations, but very little has been catalogued in reviews on the basis of their utilization and sundry issues. This paper attempts to fill this gap by assessing from literature, how effective the application of finite element analysis has been in the evaluation of the biomechanical and biodegradation behaviour of Mg-based biomedical systems which are considered for use as stents, screws, staples, and implants for orthopedic and cardiovascular applications. The review focuses on how factors such as geometric profile of the Mg based system, the material properties and applicable physical and constitutive laws, design parameters, boundary conditions stipulated, the analysis of modeling and simulation outcomes, and agreements with experimental data, influence the potentials for utilization for real life designs of Mg based biomaterial systems. Also, the challenges that could affect their effectiveness with directions on future studies for improvements, were covered. The review will be of immense benefit to researchers, biomaterial designers and clinicians. |
| first_indexed | 2024-12-18T10:17:01Z |
| format | Article |
| id | doaj.art-6c3490b3c16549a2b2206def0315cc80 |
| institution | Directory Open Access Journal |
| issn | 2588-8404 |
| language | English |
| last_indexed | 2024-12-18T10:17:01Z |
| publishDate | 2022-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | International Journal of Lightweight Materials and Manufacture |
| spelling | doaj.art-6c3490b3c16549a2b2206def0315cc802022-12-21T21:11:16ZengKeAi Communications Co., Ltd.International Journal of Lightweight Materials and Manufacture2588-84042022-06-0152251266Computational biomechanical and biodegradation integrity assessment of Mg-based biomedical devices for cardiovascular and orthopedic applications: A reviewKenneth Kanayo Alaneme0Sodiq Abiodun Kareem1Jimmy L. Olajide2Rotimi Emmanual Sadiku3Michael Oluwatosin Bodunrin4Materials Design and Structural Integrity Research Group, Department of Metallurgical and Materials Engineering, Federal University of Technology Akure, P.M.B. 704, Ondo State, Nigeria; Centre for Nanoengineering and Tribocorrosion, School of Mining, Metallurgy and Chemical Engineering, Faculty of Engineering & the Built Environment, University of Johannesburg, South Africa; Corresponding author. Materials Design and Structural Integrity Research Group, Department of Metallurgical and Materials Engineering, Federal University of Technology Akure, P.M.B. 704, Ondo State, Nigeria.Materials Design and Structural Integrity Research Group, Department of Metallurgical and Materials Engineering, Federal University of Technology Akure, P.M.B. 704, Ondo State, NigeriaDepartment of Mechanical and Automation Engineering, Faculty of Engineering and the Built Environment, Tshwane University of Technology, Pretoria, South AfricaInstitute of NanoEngineering Research (INER) and the Department of Chemical, Metallurgical and Materials Engineering, Tshwane University of Technology, Pretoria, South AfricaSchool of Chemical and Metallurgical Engineering and DSI-NRF Centre of Excellence in Strong Materials, All University of the Witwatersrand, Private Bag 3, WITS, 2050, Johannesburg, South Africa; African Academy of Sciences, P.O. Box 24916-00502, Nairobi, KenyaMagnesium and magnesium based alloys biomaterials are considered the most viable and pragmatic choice of selection as biomedical alternatives for tissue repair of damaged bones, vascular and other biological disorders. Considering the sensitivity and health implication of implanting foreign matter into the human system, extensive studies are required before clearance for clinical trials is given. This often requires rigorous experimental evaluations of biomechanical and biodegradation properties of such biomaterials, which are often expensive, time consuming and practically demanding, and requires several validation protocols. The technical advances in computing power as well as computational modeling techniques, such as finite element analysis, have been sort to address these limitations, but very little has been catalogued in reviews on the basis of their utilization and sundry issues. This paper attempts to fill this gap by assessing from literature, how effective the application of finite element analysis has been in the evaluation of the biomechanical and biodegradation behaviour of Mg-based biomedical systems which are considered for use as stents, screws, staples, and implants for orthopedic and cardiovascular applications. The review focuses on how factors such as geometric profile of the Mg based system, the material properties and applicable physical and constitutive laws, design parameters, boundary conditions stipulated, the analysis of modeling and simulation outcomes, and agreements with experimental data, influence the potentials for utilization for real life designs of Mg based biomaterial systems. Also, the challenges that could affect their effectiveness with directions on future studies for improvements, were covered. The review will be of immense benefit to researchers, biomaterial designers and clinicians.http://www.sciencedirect.com/science/article/pii/S2588840422000063Finite element analysisContinuum mechanicsBiomechanical behaviourMg based biomaterialsBiodegradationComputational techniques |
| spellingShingle | Kenneth Kanayo Alaneme Sodiq Abiodun Kareem Jimmy L. Olajide Rotimi Emmanual Sadiku Michael Oluwatosin Bodunrin Computational biomechanical and biodegradation integrity assessment of Mg-based biomedical devices for cardiovascular and orthopedic applications: A review International Journal of Lightweight Materials and Manufacture Finite element analysis Continuum mechanics Biomechanical behaviour Mg based biomaterials Biodegradation Computational techniques |
| title | Computational biomechanical and biodegradation integrity assessment of Mg-based biomedical devices for cardiovascular and orthopedic applications: A review |
| title_full | Computational biomechanical and biodegradation integrity assessment of Mg-based biomedical devices for cardiovascular and orthopedic applications: A review |
| title_fullStr | Computational biomechanical and biodegradation integrity assessment of Mg-based biomedical devices for cardiovascular and orthopedic applications: A review |
| title_full_unstemmed | Computational biomechanical and biodegradation integrity assessment of Mg-based biomedical devices for cardiovascular and orthopedic applications: A review |
| title_short | Computational biomechanical and biodegradation integrity assessment of Mg-based biomedical devices for cardiovascular and orthopedic applications: A review |
| title_sort | computational biomechanical and biodegradation integrity assessment of mg based biomedical devices for cardiovascular and orthopedic applications a review |
| topic | Finite element analysis Continuum mechanics Biomechanical behaviour Mg based biomaterials Biodegradation Computational techniques |
| url | http://www.sciencedirect.com/science/article/pii/S2588840422000063 |
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