Co-administration of albumin-furosemide in patients with the nephrotic syndrome
Generalized edema is one of the most important complications in patients with nephrotic syndrome. Diuretics like furosemide are the first choice for reducing the edema. Hypo-albuminemia reduces the effect of furosemide, and thus, this drug is co-administered with albumin to reinforce the therapeutic...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2011-01-01
|
| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2011;volume=22;issue=3;spage=471;epage=475;aulast=Ghafari |
| _version_ | 1819226866228133888 |
|---|---|
| author | Ali Ghafari Alireza Mehdizadeh Ilad Alavi-Darazam Ezatollah Rahimi Catauon Kargar Nariman Sepehrvand |
| author_facet | Ali Ghafari Alireza Mehdizadeh Ilad Alavi-Darazam Ezatollah Rahimi Catauon Kargar Nariman Sepehrvand |
| author_sort | Ali Ghafari |
| collection | DOAJ |
| description | Generalized edema is one of the most important complications in patients with nephrotic syndrome. Diuretics like furosemide are the first choice for reducing the edema. Hypo-albuminemia reduces the effect of furosemide, and thus, this drug is co-administered with albumin to reinforce the therapeutic effect and for the correction of reduced oncotic pressure. The aim of this study was to compare urine volume and 24-hour sodium levels after using furosemide alone versus using furosemide along with albumin in patients with nephrotic syndrome. In a randomized clinical trial, ten patients with nephrotic syndrome were chosen and were randomly allocated into four groups. Three therapeutic protocols were chosen, and at the end, each patient had received all three protocols randomly. Data were gathered and analyzed using non-parametric tests in SPSS software. The average urine volume after receiving albumin alone, furosemide alone and albumin plus furosemide were 742 mL (SD = 528), 1707 mL (SD = 745) and 2175 mL (SD = 971), respectively (P = 0.015); the fractional excretion of sodium was 1.96 (SD = 0.251), 3.18 (SD = 0.25), and 4.77 (SD = 8.45), respectively (P = 0.000); the 24-hour urinary sodium levels were 18.3 (SD = 6.68), 208.4 (SD = 5.27) and 206 (SD = 8.45), respectively; while the glomerular filtration rate (GFR) was 104.5, 96.6 and 106.6 (P = 0.021), respectively, in the three therapy groups. Our study shows that albumin administration alone and with furosemide in patients with nephrotic syndrome who had normal kidney function, results in different urine volumes and sodium levels. Co-administration of albumin and furosemide increased the urine volume and sodium level, which is due to increase in the GFR as well as the diuretic effects of furosemide. |
| first_indexed | 2024-12-23T10:32:18Z |
| format | Article |
| id | doaj.art-6c353c6dbc8a45c487949cd02c4a3fcf |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-23T10:32:18Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-6c353c6dbc8a45c487949cd02c4a3fcf2022-12-21T17:50:24ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422011-01-01223471475Co-administration of albumin-furosemide in patients with the nephrotic syndromeAli GhafariAlireza MehdizadehIlad Alavi-DarazamEzatollah RahimiCatauon KargarNariman SepehrvandGeneralized edema is one of the most important complications in patients with nephrotic syndrome. Diuretics like furosemide are the first choice for reducing the edema. Hypo-albuminemia reduces the effect of furosemide, and thus, this drug is co-administered with albumin to reinforce the therapeutic effect and for the correction of reduced oncotic pressure. The aim of this study was to compare urine volume and 24-hour sodium levels after using furosemide alone versus using furosemide along with albumin in patients with nephrotic syndrome. In a randomized clinical trial, ten patients with nephrotic syndrome were chosen and were randomly allocated into four groups. Three therapeutic protocols were chosen, and at the end, each patient had received all three protocols randomly. Data were gathered and analyzed using non-parametric tests in SPSS software. The average urine volume after receiving albumin alone, furosemide alone and albumin plus furosemide were 742 mL (SD = 528), 1707 mL (SD = 745) and 2175 mL (SD = 971), respectively (P = 0.015); the fractional excretion of sodium was 1.96 (SD = 0.251), 3.18 (SD = 0.25), and 4.77 (SD = 8.45), respectively (P = 0.000); the 24-hour urinary sodium levels were 18.3 (SD = 6.68), 208.4 (SD = 5.27) and 206 (SD = 8.45), respectively; while the glomerular filtration rate (GFR) was 104.5, 96.6 and 106.6 (P = 0.021), respectively, in the three therapy groups. Our study shows that albumin administration alone and with furosemide in patients with nephrotic syndrome who had normal kidney function, results in different urine volumes and sodium levels. Co-administration of albumin and furosemide increased the urine volume and sodium level, which is due to increase in the GFR as well as the diuretic effects of furosemide.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2011;volume=22;issue=3;spage=471;epage=475;aulast=Ghafari |
| spellingShingle | Ali Ghafari Alireza Mehdizadeh Ilad Alavi-Darazam Ezatollah Rahimi Catauon Kargar Nariman Sepehrvand Co-administration of albumin-furosemide in patients with the nephrotic syndrome Saudi Journal of Kidney Diseases and Transplantation |
| title | Co-administration of albumin-furosemide in patients with the nephrotic syndrome |
| title_full | Co-administration of albumin-furosemide in patients with the nephrotic syndrome |
| title_fullStr | Co-administration of albumin-furosemide in patients with the nephrotic syndrome |
| title_full_unstemmed | Co-administration of albumin-furosemide in patients with the nephrotic syndrome |
| title_short | Co-administration of albumin-furosemide in patients with the nephrotic syndrome |
| title_sort | co administration of albumin furosemide in patients with the nephrotic syndrome |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2011;volume=22;issue=3;spage=471;epage=475;aulast=Ghafari |
| work_keys_str_mv | AT alighafari coadministrationofalbuminfurosemideinpatientswiththenephroticsyndrome AT alirezamehdizadeh coadministrationofalbuminfurosemideinpatientswiththenephroticsyndrome AT iladalavidarazam coadministrationofalbuminfurosemideinpatientswiththenephroticsyndrome AT ezatollahrahimi coadministrationofalbuminfurosemideinpatientswiththenephroticsyndrome AT catauonkargar coadministrationofalbuminfurosemideinpatientswiththenephroticsyndrome AT narimansepehrvand coadministrationofalbuminfurosemideinpatientswiththenephroticsyndrome |