The Synthesis of Novel 2-Hetarylthiazoles via the Stille Reaction
A preparative approach to the synthesis of 2-hetaryl thiazoles has been developed via the interaction of halothiazoles with stannanes according to the Stille reaction. The most effective catalysts and reaction conditions have been found. It has been determined that the formation of by-products occur...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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National University of Pharmacy (Kharkiv)
2023-10-01
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| Series: | Журнал органічної та фармацевтичної хімії |
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| Online Access: | https://ophcj.nuph.edu.ua/article/view/288204 |
| _version_ | 1827159737784860672 |
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| author | Dmytro O. Tarasenko Volodymyr M. Kotliar |
| author_facet | Dmytro O. Tarasenko Volodymyr M. Kotliar |
| author_sort | Dmytro O. Tarasenko |
| collection | DOAJ |
| description | A preparative approach to the synthesis of 2-hetaryl thiazoles has been developed via the interaction of halothiazoles with stannanes according to the Stille reaction. The most effective catalysts and reaction conditions have been found. It has been determined that the formation of by-products occurs due to specific interaction of the corresponding stannanes with the carbonyl group. The by-products have been isolated and characterized. The mechanism of this interaction with the carbonyl group has not been described in literature. The 2-hetaryl thiazoles obtained have great potential as new building blocks for medicinal chemistry and as ligands due to their complexing properties. |
| first_indexed | 2024-03-09T14:21:31Z |
| format | Article |
| id | doaj.art-6c35ff5f43c544828b87a6318cf5fb7e |
| institution | Directory Open Access Journal |
| issn | 2308-8303 2518-1548 |
| language | English |
| last_indexed | 2025-03-21T00:01:53Z |
| publishDate | 2023-10-01 |
| publisher | National University of Pharmacy (Kharkiv) |
| record_format | Article |
| series | Журнал органічної та фармацевтичної хімії |
| spelling | doaj.art-6c35ff5f43c544828b87a6318cf5fb7e2024-08-03T11:28:04ZengNational University of Pharmacy (Kharkiv)Журнал органічної та фармацевтичної хімії2308-83032518-15482023-10-012131722https://doi.org/10.24959/ophcj.23.288204The Synthesis of Novel 2-Hetarylthiazoles via the Stille ReactionDmytro O. Tarasenko0https://orcid.org/0009-0004-3123-1976Volodymyr M. Kotliar1https://orcid.org/0000-0003-0632-7453V. N. Karazin Kharkiv National University, UkraineV. N. Karazin Kharkiv National University, UkraineA preparative approach to the synthesis of 2-hetaryl thiazoles has been developed via the interaction of halothiazoles with stannanes according to the Stille reaction. The most effective catalysts and reaction conditions have been found. It has been determined that the formation of by-products occurs due to specific interaction of the corresponding stannanes with the carbonyl group. The by-products have been isolated and characterized. The mechanism of this interaction with the carbonyl group has not been described in literature. The 2-hetaryl thiazoles obtained have great potential as new building blocks for medicinal chemistry and as ligands due to their complexing properties.https://ophcj.nuph.edu.ua/article/view/288204stille reactionheterocyclethiazolebuchwald catalystschalcone |
| spellingShingle | Dmytro O. Tarasenko Volodymyr M. Kotliar The Synthesis of Novel 2-Hetarylthiazoles via the Stille Reaction Журнал органічної та фармацевтичної хімії stille reaction heterocycle thiazole buchwald catalysts chalcone |
| title | The Synthesis of Novel 2-Hetarylthiazoles via the Stille Reaction |
| title_full | The Synthesis of Novel 2-Hetarylthiazoles via the Stille Reaction |
| title_fullStr | The Synthesis of Novel 2-Hetarylthiazoles via the Stille Reaction |
| title_full_unstemmed | The Synthesis of Novel 2-Hetarylthiazoles via the Stille Reaction |
| title_short | The Synthesis of Novel 2-Hetarylthiazoles via the Stille Reaction |
| title_sort | synthesis of novel 2 hetarylthiazoles via the stille reaction |
| topic | stille reaction heterocycle thiazole buchwald catalysts chalcone |
| url | https://ophcj.nuph.edu.ua/article/view/288204 |
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