Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes
<p>Abstract</p> <p>Background</p> <p>An early sign of heart failure (HF) is a decreased cardiac reserve or inability to adequately increase cardiac output during exercise. Under normal circumstances maximal cardiac output is closely related to peak oxygen uptake (VO<...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-12-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Online Access: | http://www.jcmr-online.com/content/12/1/74 |
| _version_ | 1797203433873211392 |
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| author | Buhre Torsten Hedén Bo Mosén Henrik Carlsson Marcus Steding Katarina Engblom Henrik Ekmehag Björn Arheden Håkan |
| author_facet | Buhre Torsten Hedén Bo Mosén Henrik Carlsson Marcus Steding Katarina Engblom Henrik Ekmehag Björn Arheden Håkan |
| author_sort | Buhre Torsten |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>An early sign of heart failure (HF) is a decreased cardiac reserve or inability to adequately increase cardiac output during exercise. Under normal circumstances maximal cardiac output is closely related to peak oxygen uptake (VO<sub>2</sub>peak) which has previously been shown to be closely related to total heart volume (THV). Thus, the aim of this study was to derive a VO<sub>2</sub>peak/THV ratio and to test the hypothesis that this ratio can be used to distinguish patients with HF from healthy volunteers and endurance athletes. Thirty-one patients with HF of different etiologies were retrospectively included and 131 control subjects (60 healthy volunteers and 71 athletes) were prospectively enrolled. Peak oxygen uptake was determined by maximal exercise test and THV was determined by cardiovascular magnetic resonance. The VO<sub>2</sub>peak/THV ratio was then derived and tested.</p> <p>Results</p> <p>Peak oxygen uptake was strongly correlated to THV (r<sup>2 </sup>= 0.74, p < 0.001) in the control subjects, but not for the patients (r<sup>2 </sup>= 0.0002, p = 0.95). The VO<sub>2</sub>peak/THV ratio differed significantly between control subjects and patients, even in patients with normal ejection fraction and after normalizing for hemoglobin levels (p < 0.001). In a multivariate analysis the VO<sub>2</sub>peak/THV ratio was the only independent predictor of presence of HF (p < 0.001).</p> <p>Conclusions</p> <p>The VO<sub>2</sub>peak/THV ratio can be used to distinguish patients with clinically diagnosed HF from healthy volunteers and athletes, even in patients with preserved systolic left ventricular function and after normalizing for hemoglobin levels.</p> |
| first_indexed | 2024-04-24T08:19:16Z |
| format | Article |
| id | doaj.art-6c374286aa304244832ae4c9ec3f0894 |
| institution | Directory Open Access Journal |
| issn | 1097-6647 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:19:16Z |
| publishDate | 2010-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-6c374286aa304244832ae4c9ec3f08942024-04-17T02:25:03ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2010-12-011217410.1186/1532-429X-12-74Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletesBuhre TorstenHedén BoMosén HenrikCarlsson MarcusSteding KatarinaEngblom HenrikEkmehag BjörnArheden Håkan<p>Abstract</p> <p>Background</p> <p>An early sign of heart failure (HF) is a decreased cardiac reserve or inability to adequately increase cardiac output during exercise. Under normal circumstances maximal cardiac output is closely related to peak oxygen uptake (VO<sub>2</sub>peak) which has previously been shown to be closely related to total heart volume (THV). Thus, the aim of this study was to derive a VO<sub>2</sub>peak/THV ratio and to test the hypothesis that this ratio can be used to distinguish patients with HF from healthy volunteers and endurance athletes. Thirty-one patients with HF of different etiologies were retrospectively included and 131 control subjects (60 healthy volunteers and 71 athletes) were prospectively enrolled. Peak oxygen uptake was determined by maximal exercise test and THV was determined by cardiovascular magnetic resonance. The VO<sub>2</sub>peak/THV ratio was then derived and tested.</p> <p>Results</p> <p>Peak oxygen uptake was strongly correlated to THV (r<sup>2 </sup>= 0.74, p < 0.001) in the control subjects, but not for the patients (r<sup>2 </sup>= 0.0002, p = 0.95). The VO<sub>2</sub>peak/THV ratio differed significantly between control subjects and patients, even in patients with normal ejection fraction and after normalizing for hemoglobin levels (p < 0.001). In a multivariate analysis the VO<sub>2</sub>peak/THV ratio was the only independent predictor of presence of HF (p < 0.001).</p> <p>Conclusions</p> <p>The VO<sub>2</sub>peak/THV ratio can be used to distinguish patients with clinically diagnosed HF from healthy volunteers and athletes, even in patients with preserved systolic left ventricular function and after normalizing for hemoglobin levels.</p>http://www.jcmr-online.com/content/12/1/74 |
| spellingShingle | Buhre Torsten Hedén Bo Mosén Henrik Carlsson Marcus Steding Katarina Engblom Henrik Ekmehag Björn Arheden Håkan Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes Journal of Cardiovascular Magnetic Resonance |
| title | Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes |
| title_full | Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes |
| title_fullStr | Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes |
| title_full_unstemmed | Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes |
| title_short | Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes |
| title_sort | peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes |
| url | http://www.jcmr-online.com/content/12/1/74 |
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