Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity
Natural polyphenols, frequently called secondary metabolites, play an important role in cancer prevention and treatment. Polyphenols are characterized by high structural diversity, which translates into a very wide therapeutic spectrum, including antioxidant, anti-inflammatory, proapoptotic, anti-an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618302093 |
| _version_ | 1830353560572788736 |
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| author | Katarzyna Chojnacka Urszula Lewandowska |
| author_facet | Katarzyna Chojnacka Urszula Lewandowska |
| author_sort | Katarzyna Chojnacka |
| collection | DOAJ |
| description | Natural polyphenols, frequently called secondary metabolites, play an important role in cancer prevention and treatment. Polyphenols are characterized by high structural diversity, which translates into a very wide therapeutic spectrum, including antioxidant, anti-inflammatory, proapoptotic, anti-angiogenic and anti-metastatic activities. These compounds can modulate the activities of some functional proteins and enzymes, such as matrix metalloproteinases, including type IV collagenases (MMP-2 and MMP-9). Type IV collagenases are able to degrade the protein components of the extracellular matrix and play key roles in physiological processes, such as tissue repair and morphogenesis, as well as in carcinogenesis and other pathological processes. This review discusses the current state of knowledge concerning the anti-invasion and anti-metastatic potential of natural polyphenol-rich extracts, with a focus on in vitro and in vivo evidence. Based on these findings, plant extracts may be a promising alternative strategy to synthetic MMP-2/-9 inhibitors of cancer invasiveness and metastasis. |
| first_indexed | 2024-12-20T01:15:43Z |
| format | Article |
| id | doaj.art-6c39470db7e54d3491af9ad1666ce544 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T01:15:43Z |
| publishDate | 2018-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6c39470db7e54d3491af9ad1666ce5442022-12-21T19:58:34ZengElsevierJournal of Functional Foods1756-46462018-07-0146295311Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activityKatarzyna Chojnacka0Urszula Lewandowska1Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, PolandCorresponding author at: Department of Biochemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, PolandNatural polyphenols, frequently called secondary metabolites, play an important role in cancer prevention and treatment. Polyphenols are characterized by high structural diversity, which translates into a very wide therapeutic spectrum, including antioxidant, anti-inflammatory, proapoptotic, anti-angiogenic and anti-metastatic activities. These compounds can modulate the activities of some functional proteins and enzymes, such as matrix metalloproteinases, including type IV collagenases (MMP-2 and MMP-9). Type IV collagenases are able to degrade the protein components of the extracellular matrix and play key roles in physiological processes, such as tissue repair and morphogenesis, as well as in carcinogenesis and other pathological processes. This review discusses the current state of knowledge concerning the anti-invasion and anti-metastatic potential of natural polyphenol-rich extracts, with a focus on in vitro and in vivo evidence. Based on these findings, plant extracts may be a promising alternative strategy to synthetic MMP-2/-9 inhibitors of cancer invasiveness and metastasis.http://www.sciencedirect.com/science/article/pii/S1756464618302093Polyphenol-rich extractsMMP-2MMP-9InvasivenessMetastasisChemoprevention |
| spellingShingle | Katarzyna Chojnacka Urszula Lewandowska Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity Journal of Functional Foods Polyphenol-rich extracts MMP-2 MMP-9 Invasiveness Metastasis Chemoprevention |
| title | Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity |
| title_full | Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity |
| title_fullStr | Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity |
| title_full_unstemmed | Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity |
| title_short | Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity |
| title_sort | chemopreventive effects of polyphenol rich extracts against cancer invasiveness and metastasis by inhibition of type iv collagenases expression and activity |
| topic | Polyphenol-rich extracts MMP-2 MMP-9 Invasiveness Metastasis Chemoprevention |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618302093 |
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