The involvement of microRNAs in HCV and HIV infection
Approximately 2.3 million people are suffering from human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection worldwide. Faster disease progression and increased mortality rates during the HIV/HCV co-infection have become global health concerns. Effective therapeutics against co-infect...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-06-01
|
| Series: | Therapeutic Advances in Vaccines and Immunotherapy |
| Online Access: | https://doi.org/10.1177/25151355221106104 |
| _version_ | 1811325898962501632 |
|---|---|
| author | Nicky Joshi Madhuri Chandane Tak Anupam Mukherjee |
| author_facet | Nicky Joshi Madhuri Chandane Tak Anupam Mukherjee |
| author_sort | Nicky Joshi |
| collection | DOAJ |
| description | Approximately 2.3 million people are suffering from human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection worldwide. Faster disease progression and increased mortality rates during the HIV/HCV co-infection have become global health concerns. Effective therapeutics against co-infection and complete infection eradication has become a mandatory requirement. The study of small non-coding RNAs in cellular processes and viral infection has so far been beneficial in various terms. Currently, microRNAs are an influential candidate for disease diagnosis and treatment. Dysregulation in miRNA expression can lead to unfavorable outcomes; hence, this exact inevitable nature has made various studies a focal point. A considerable improvement in comprehending HIV and HCV mono-infection pathogenesis is seen using miRNAs. The prominent reason behind HIV/HCV co-infection is seen to be their standard route of transmission, while some pieces of evidence also suspect viral interplay between having a role in increased viral infection. This review highlights the involvement of microRNAs in HIV/HCV co-infection, along with their contribution in HIV mono- and HCV mono-infection. We also discuss miRNAs that carry the potentiality of becoming a biomarker for viral infection and early disease progression. |
| first_indexed | 2024-04-13T14:41:26Z |
| format | Article |
| id | doaj.art-6c3cf38b661442ceab13174c102b90bd |
| institution | Directory Open Access Journal |
| issn | 2515-1363 |
| language | English |
| last_indexed | 2024-04-13T14:41:26Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Vaccines and Immunotherapy |
| spelling | doaj.art-6c3cf38b661442ceab13174c102b90bd2022-12-22T02:42:53ZengSAGE PublishingTherapeutic Advances in Vaccines and Immunotherapy2515-13632022-06-011010.1177/25151355221106104The involvement of microRNAs in HCV and HIV infectionNicky JoshiMadhuri Chandane TakAnupam MukherjeeApproximately 2.3 million people are suffering from human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection worldwide. Faster disease progression and increased mortality rates during the HIV/HCV co-infection have become global health concerns. Effective therapeutics against co-infection and complete infection eradication has become a mandatory requirement. The study of small non-coding RNAs in cellular processes and viral infection has so far been beneficial in various terms. Currently, microRNAs are an influential candidate for disease diagnosis and treatment. Dysregulation in miRNA expression can lead to unfavorable outcomes; hence, this exact inevitable nature has made various studies a focal point. A considerable improvement in comprehending HIV and HCV mono-infection pathogenesis is seen using miRNAs. The prominent reason behind HIV/HCV co-infection is seen to be their standard route of transmission, while some pieces of evidence also suspect viral interplay between having a role in increased viral infection. This review highlights the involvement of microRNAs in HIV/HCV co-infection, along with their contribution in HIV mono- and HCV mono-infection. We also discuss miRNAs that carry the potentiality of becoming a biomarker for viral infection and early disease progression.https://doi.org/10.1177/25151355221106104 |
| spellingShingle | Nicky Joshi Madhuri Chandane Tak Anupam Mukherjee The involvement of microRNAs in HCV and HIV infection Therapeutic Advances in Vaccines and Immunotherapy |
| title | The involvement of microRNAs in HCV and HIV infection |
| title_full | The involvement of microRNAs in HCV and HIV infection |
| title_fullStr | The involvement of microRNAs in HCV and HIV infection |
| title_full_unstemmed | The involvement of microRNAs in HCV and HIV infection |
| title_short | The involvement of microRNAs in HCV and HIV infection |
| title_sort | involvement of micrornas in hcv and hiv infection |
| url | https://doi.org/10.1177/25151355221106104 |
| work_keys_str_mv | AT nickyjoshi theinvolvementofmicrornasinhcvandhivinfection AT madhurichandanetak theinvolvementofmicrornasinhcvandhivinfection AT anupammukherjee theinvolvementofmicrornasinhcvandhivinfection AT nickyjoshi involvementofmicrornasinhcvandhivinfection AT madhurichandanetak involvementofmicrornasinhcvandhivinfection AT anupammukherjee involvementofmicrornasinhcvandhivinfection |