Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia.
The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequen...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0224658 |
| _version_ | 1819044437641134080 |
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| author | Heng Choon Cheong Polly Soo Xi Yap Chun Wie Chong Yi Ying Cheok Chalystha Yie Qin Lee Grace Min Yi Tan Sofiah Sulaiman Jamiyah Hassan Negar Shafiei Sabet Chung Yeng Looi Rishein Gupta Bernard Arulanandam Sazaly AbuBakar Cindy Shuan Ju Teh Li Yen Chang Won Fen Wong |
| author_facet | Heng Choon Cheong Polly Soo Xi Yap Chun Wie Chong Yi Ying Cheok Chalystha Yie Qin Lee Grace Min Yi Tan Sofiah Sulaiman Jamiyah Hassan Negar Shafiei Sabet Chung Yeng Looi Rishein Gupta Bernard Arulanandam Sazaly AbuBakar Cindy Shuan Ju Teh Li Yen Chang Won Fen Wong |
| author_sort | Heng Choon Cheong |
| collection | DOAJ |
| description | The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In this study, we profiled the cervical microbial composition of a population of 70 reproductive-age Malaysian women; among which 40 (57.1%) were diagnosed with genital C. trachomatis infection, and 30 (42.8%) without C. trachomatis infection. Our findings showed a distinct compositional difference between the cervical microbiota of C. trachomatis-infected subjects and subjects without C. trachomatis infection. Specifically, significant elevations of mostly strict and facultative anaerobes such as Streptococcus, Megasphaera, Prevotella, and Veillonella in the cervical microbiota of C. trachomatis-positive women were detected. The results from the current study highlights an interaction of C. trachomatis with the environmental microbiome in the endocervical region. |
| first_indexed | 2024-12-21T10:12:40Z |
| format | Article |
| id | doaj.art-6c3d2a140b0b4aaaac4755b485f09f06 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T10:12:40Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6c3d2a140b0b4aaaac4755b485f09f062022-12-21T19:07:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011411e022465810.1371/journal.pone.0224658Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia.Heng Choon CheongPolly Soo Xi YapChun Wie ChongYi Ying CheokChalystha Yie Qin LeeGrace Min Yi TanSofiah SulaimanJamiyah HassanNegar Shafiei SabetChung Yeng LooiRishein GuptaBernard ArulanandamSazaly AbuBakarCindy Shuan Ju TehLi Yen ChangWon Fen WongThe cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In this study, we profiled the cervical microbial composition of a population of 70 reproductive-age Malaysian women; among which 40 (57.1%) were diagnosed with genital C. trachomatis infection, and 30 (42.8%) without C. trachomatis infection. Our findings showed a distinct compositional difference between the cervical microbiota of C. trachomatis-infected subjects and subjects without C. trachomatis infection. Specifically, significant elevations of mostly strict and facultative anaerobes such as Streptococcus, Megasphaera, Prevotella, and Veillonella in the cervical microbiota of C. trachomatis-positive women were detected. The results from the current study highlights an interaction of C. trachomatis with the environmental microbiome in the endocervical region.https://doi.org/10.1371/journal.pone.0224658 |
| spellingShingle | Heng Choon Cheong Polly Soo Xi Yap Chun Wie Chong Yi Ying Cheok Chalystha Yie Qin Lee Grace Min Yi Tan Sofiah Sulaiman Jamiyah Hassan Negar Shafiei Sabet Chung Yeng Looi Rishein Gupta Bernard Arulanandam Sazaly AbuBakar Cindy Shuan Ju Teh Li Yen Chang Won Fen Wong Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia. PLoS ONE |
| title | Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia. |
| title_full | Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia. |
| title_fullStr | Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia. |
| title_full_unstemmed | Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia. |
| title_short | Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia. |
| title_sort | diversity of endocervical microbiota associated with genital chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in malaysia |
| url | https://doi.org/10.1371/journal.pone.0224658 |
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