Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role
The aim of this study was to evaluate the relationship between anaemia and biomarkers of central/peripheral congestion in heart failure (HF) and the impact on mortality. We retrospectively evaluated 434 acute/chronic HF (AHF/CHF) patients. Anaemia was defined as haemoglobin levels <12 g/dL (women...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/3/972 |
| _version_ | 1797613273710854144 |
|---|---|
| author | Pietro Scicchitano Massimo Iacoviello Antonio Massari Micaela De Palo Angela Potenza Raffaella Landriscina Silvia Abruzzese Maria Tangorra Piero Guida Marco Matteo Ciccone Pasquale Caldarola Francesco Massari |
| author_facet | Pietro Scicchitano Massimo Iacoviello Antonio Massari Micaela De Palo Angela Potenza Raffaella Landriscina Silvia Abruzzese Maria Tangorra Piero Guida Marco Matteo Ciccone Pasquale Caldarola Francesco Massari |
| author_sort | Pietro Scicchitano |
| collection | DOAJ |
| description | The aim of this study was to evaluate the relationship between anaemia and biomarkers of central/peripheral congestion in heart failure (HF) and the impact on mortality. We retrospectively evaluated 434 acute/chronic HF (AHF/CHF) patients. Anaemia was defined as haemoglobin levels <12 g/dL (women) or <13 g/dL (men). The brain natriuretic peptide (BNP) and hydration index (HI) were measured. The endpoint of the study was all-cause mortality. Anaemia occurred in 59% of patients with AHF and in 35% with CHF (<i>p</i> < 0.001) and showed a significant correlation with the NYHA functional class and renal function. BNP and HI were significantly higher in patients with anaemia than in those without anaemia. Independent predictors of anaemia included BNP, estimated creatinine clearance (eCrCL), and HI. The all-cause mortality rate was 21%, which was significantly higher in patients with anaemia than in those without anaemia (30% vs. 14%, <i>p</i> < 0.001; hazard ratio: 2.6). At multivariate Cox regression analysis, BNP, eCrCL, and HI were independent predictors for mortality (Hazard ratios: 1.0002, 0.97, and 1.05, respectively), while anaemia was not. Anaemia correlates with HF status, functional class, renal function, BNP, and HI. Anaemia was not an independent predictor for mortality, acting as a disease severity marker in congestive patients rather than as a predictor of death. |
| first_indexed | 2024-03-11T06:53:33Z |
| format | Article |
| id | doaj.art-6c3e7c27e1db4f88b001ce3e0bc4a7e3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:33Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-6c3e7c27e1db4f88b001ce3e0bc4a7e32023-11-17T09:48:18ZengMDPI AGBiomedicines2227-90592023-03-0111397210.3390/biomedicines11030972Anaemia and Congestion in Heart Failure: Correlations and Prognostic RolePietro Scicchitano0Massimo Iacoviello1Antonio Massari2Micaela De Palo3Angela Potenza4Raffaella Landriscina5Silvia Abruzzese6Maria Tangorra7Piero Guida8Marco Matteo Ciccone9Pasquale Caldarola10Francesco Massari11Cardiology Section, Hospital “F. Perinei” Altamura, 70022 Altamura, ItalyCardiology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyKorian Italia, 70021 Acquaviva delle Fonti, ItalyCardiac Surgery Unit, Policlinic University Hospital, 70124 Bari, ItalyCardiology Section, Hospital “F. Perinei” Altamura, 70022 Altamura, ItalyCardiology Section, Hospital “F. Perinei” Altamura, 70022 Altamura, ItalyCardiology Section, Hospital “F. Perinei” Altamura, 70022 Altamura, ItalyCardiology Section, Hospital “F. Perinei” Altamura, 70022 Altamura, ItalyOspedale Generale Regionale “F. Miulli”, 70021 Acquaviva delle Fonti, ItalyCardiology Unit, Policlinic University Hospital, Piazza Giulio Cesare 11, 70124 Bari, ItalyCardiology Section, Hospital “S. Paolo”, 70124 Bari, ItalyCardiology Section, Hospital “F. Perinei” Altamura, 70022 Altamura, ItalyThe aim of this study was to evaluate the relationship between anaemia and biomarkers of central/peripheral congestion in heart failure (HF) and the impact on mortality. We retrospectively evaluated 434 acute/chronic HF (AHF/CHF) patients. Anaemia was defined as haemoglobin levels <12 g/dL (women) or <13 g/dL (men). The brain natriuretic peptide (BNP) and hydration index (HI) were measured. The endpoint of the study was all-cause mortality. Anaemia occurred in 59% of patients with AHF and in 35% with CHF (<i>p</i> < 0.001) and showed a significant correlation with the NYHA functional class and renal function. BNP and HI were significantly higher in patients with anaemia than in those without anaemia. Independent predictors of anaemia included BNP, estimated creatinine clearance (eCrCL), and HI. The all-cause mortality rate was 21%, which was significantly higher in patients with anaemia than in those without anaemia (30% vs. 14%, <i>p</i> < 0.001; hazard ratio: 2.6). At multivariate Cox regression analysis, BNP, eCrCL, and HI were independent predictors for mortality (Hazard ratios: 1.0002, 0.97, and 1.05, respectively), while anaemia was not. Anaemia correlates with HF status, functional class, renal function, BNP, and HI. Anaemia was not an independent predictor for mortality, acting as a disease severity marker in congestive patients rather than as a predictor of death.https://www.mdpi.com/2227-9059/11/3/972heart failureBIVABNPanaemiaprognosiscongestion |
| spellingShingle | Pietro Scicchitano Massimo Iacoviello Antonio Massari Micaela De Palo Angela Potenza Raffaella Landriscina Silvia Abruzzese Maria Tangorra Piero Guida Marco Matteo Ciccone Pasquale Caldarola Francesco Massari Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role Biomedicines heart failure BIVA BNP anaemia prognosis congestion |
| title | Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role |
| title_full | Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role |
| title_fullStr | Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role |
| title_full_unstemmed | Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role |
| title_short | Anaemia and Congestion in Heart Failure: Correlations and Prognostic Role |
| title_sort | anaemia and congestion in heart failure correlations and prognostic role |
| topic | heart failure BIVA BNP anaemia prognosis congestion |
| url | https://www.mdpi.com/2227-9059/11/3/972 |
| work_keys_str_mv | AT pietroscicchitano anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT massimoiacoviello anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT antoniomassari anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT micaeladepalo anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT angelapotenza anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT raffaellalandriscina anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT silviaabruzzese anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT mariatangorra anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT pieroguida anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT marcomatteociccone anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT pasqualecaldarola anaemiaandcongestioninheartfailurecorrelationsandprognosticrole AT francescomassari anaemiaandcongestioninheartfailurecorrelationsandprognosticrole |