Sex and Cross-Sex Testosterone Treatment Alters Gamma-Hydroxybutyrate Acid Toxicokinetics and Toxicodynamics in Rats

Sex and Cross-Sex Testosterone Treatment Alters Gamma-Hydroxybutyrate Acid Toxicokinetics and Toxicodynamics in Rats

Γ-hydroxybutyric acid (GHB) is widely abused due to its sedative/hypnotic and euphoric effects. In recent years, GHB use has witnessed a notable rise within the LGBTQ+ community. GHB is a substrate of monocarboxylate transporters (MCTs) and exhibits nonlinear toxicokinetics, characterized by saturab...

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Bibliographic Details
Main Authors:	Qing Zhang, Hao Wei, Annie Lee, Melanie A. Felmlee
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	Pharmaceutics
Subjects:	gamma-hydroxybutyrate toxicokinetics pharmacokinetics pharmacodynamics monocarboxylate transporters transporter inhibition
Online Access:	https://www.mdpi.com/1999-4923/16/1/143

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