Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Communications Physics |
| Online Access: | https://doi.org/10.1038/s42005-021-00582-8 |
| Summary: | Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison of the effects on the human interactome of SARS-CoV-2 with respect to other viruses, and find that COVID-19 exhibits properties typical of systemic diseases. |
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| ISSN: | 2399-3650 |