Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Communications Physics |
| Online Access: | https://doi.org/10.1038/s42005-021-00582-8 |
| _version_ | 1818403142310559744 |
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| author | Arsham Ghavasieh Sebastiano Bontorin Oriol Artime Nina Verstraete Manlio De Domenico |
| author_facet | Arsham Ghavasieh Sebastiano Bontorin Oriol Artime Nina Verstraete Manlio De Domenico |
| author_sort | Arsham Ghavasieh |
| collection | DOAJ |
| description | Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison of the effects on the human interactome of SARS-CoV-2 with respect to other viruses, and find that COVID-19 exhibits properties typical of systemic diseases. |
| first_indexed | 2024-12-14T08:19:33Z |
| format | Article |
| id | doaj.art-6c3ec879512740d28f17babc13acf0d4 |
| institution | Directory Open Access Journal |
| issn | 2399-3650 |
| language | English |
| last_indexed | 2024-12-14T08:19:33Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Physics |
| spelling | doaj.art-6c3ec879512740d28f17babc13acf0d42022-12-21T23:09:50ZengNature PortfolioCommunications Physics2399-36502021-04-014111310.1038/s42005-021-00582-8Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infectionsArsham Ghavasieh0Sebastiano Bontorin1Oriol Artime2Nina Verstraete3Manlio De Domenico4Fondazione Bruno KesslerFondazione Bruno KesslerFondazione Bruno KesslerCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 Inserm, ERL5294 CNRSFondazione Bruno KesslerCharacterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison of the effects on the human interactome of SARS-CoV-2 with respect to other viruses, and find that COVID-19 exhibits properties typical of systemic diseases.https://doi.org/10.1038/s42005-021-00582-8 |
| spellingShingle | Arsham Ghavasieh Sebastiano Bontorin Oriol Artime Nina Verstraete Manlio De Domenico Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections Communications Physics |
| title | Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections |
| title_full | Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections |
| title_fullStr | Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections |
| title_full_unstemmed | Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections |
| title_short | Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections |
| title_sort | multiscale statistical physics of the pan viral interactome unravels the systemic nature of sars cov 2 infections |
| url | https://doi.org/10.1038/s42005-021-00582-8 |
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