Tau secretion is correlated to an increase of Golgi dynamics.
Tau protein can be released by neurons, an event linked to the propagation of Tau pathology in Alzheimer'disease (AD). Neuronal hyperexcitability was shown to significantly increase Tau release by neurons. We confirmed this in the present study. In a previous study, it was demonstrated that hyp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5446162?pdf=render |
| _version_ | 1828434239532564480 |
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| author | Nguyen-Vi Mohamed Alexandre Desjardins Nicole Leclerc |
| author_facet | Nguyen-Vi Mohamed Alexandre Desjardins Nicole Leclerc |
| author_sort | Nguyen-Vi Mohamed |
| collection | DOAJ |
| description | Tau protein can be released by neurons, an event linked to the propagation of Tau pathology in Alzheimer'disease (AD). Neuronal hyperexcitability was shown to significantly increase Tau release by neurons. We confirmed this in the present study. In a previous study, it was demonstrated that hyperexcitability induces Golgi apparatus dynamics resulting in its fragmentation. Our present results revealed that the increase of Tau secretion upon hyperexcitability could be significantly reduced by preventing Golgi dynamics through the inactivation of cdk5. We then verified whether a Golgi fragmentation not induced by hyperexcitability could also increase Tau secretion. The suppression of Rab1A, Rab GTPase associated with the Golgi membranes, known to induce a Golgi fragmentation increased Tau secretion by both neurons and HeLa cells. Although it remains to be demonstrated whether the Golgi is directly involved in Tau secretion, the present results demonstrate that its dynamics are correlated to a modulation of Tau secretion. |
| first_indexed | 2024-12-10T18:47:29Z |
| format | Article |
| id | doaj.art-6c40ad3fa3b7459db140140889152def |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T18:47:29Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6c40ad3fa3b7459db140140889152def2022-12-22T01:37:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017828810.1371/journal.pone.0178288Tau secretion is correlated to an increase of Golgi dynamics.Nguyen-Vi MohamedAlexandre DesjardinsNicole LeclercTau protein can be released by neurons, an event linked to the propagation of Tau pathology in Alzheimer'disease (AD). Neuronal hyperexcitability was shown to significantly increase Tau release by neurons. We confirmed this in the present study. In a previous study, it was demonstrated that hyperexcitability induces Golgi apparatus dynamics resulting in its fragmentation. Our present results revealed that the increase of Tau secretion upon hyperexcitability could be significantly reduced by preventing Golgi dynamics through the inactivation of cdk5. We then verified whether a Golgi fragmentation not induced by hyperexcitability could also increase Tau secretion. The suppression of Rab1A, Rab GTPase associated with the Golgi membranes, known to induce a Golgi fragmentation increased Tau secretion by both neurons and HeLa cells. Although it remains to be demonstrated whether the Golgi is directly involved in Tau secretion, the present results demonstrate that its dynamics are correlated to a modulation of Tau secretion.http://europepmc.org/articles/PMC5446162?pdf=render |
| spellingShingle | Nguyen-Vi Mohamed Alexandre Desjardins Nicole Leclerc Tau secretion is correlated to an increase of Golgi dynamics. PLoS ONE |
| title | Tau secretion is correlated to an increase of Golgi dynamics. |
| title_full | Tau secretion is correlated to an increase of Golgi dynamics. |
| title_fullStr | Tau secretion is correlated to an increase of Golgi dynamics. |
| title_full_unstemmed | Tau secretion is correlated to an increase of Golgi dynamics. |
| title_short | Tau secretion is correlated to an increase of Golgi dynamics. |
| title_sort | tau secretion is correlated to an increase of golgi dynamics |
| url | http://europepmc.org/articles/PMC5446162?pdf=render |
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