New Eco-Friendly, Biocompatible, Bactericidal, Fungicidal and Anticancer-Activity-Exhibiting Nanocomposites Based on Bimetallic TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> Nanoparticle Core and Biopolymer Shells
Nanoparticles have attracted substantial attention for their diverse range of applications, particularly in biomedicine applications and drug delivery, owing to their unique properties. However, their tiny size facilitates easy cellular entry, which can also lead to interactions with cellular compon...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Journal of Composites Science |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2504-477X/7/10/426 |
| _version_ | 1797573381042733056 |
|---|---|
| author | Mohamed S. Hasanin Yasser Elhenawy Shereen M. S. Abdel-Hamid Yasser Fouad Toderaș Monica O. A. Al-Qabandi Miroslawa El Fray Mohamed Bassyouni |
| author_facet | Mohamed S. Hasanin Yasser Elhenawy Shereen M. S. Abdel-Hamid Yasser Fouad Toderaș Monica O. A. Al-Qabandi Miroslawa El Fray Mohamed Bassyouni |
| author_sort | Mohamed S. Hasanin |
| collection | DOAJ |
| description | Nanoparticles have attracted substantial attention for their diverse range of applications, particularly in biomedicine applications and drug delivery, owing to their unique properties. However, their tiny size facilitates easy cellular entry, which can also lead to interactions with cellular components, potentially resulting in toxicity and undesirable effects. In this study, a novel nanocomposite formulation was developed using biopolymers, specifically ethylcellulose and collagen, as capping and stabilizing agents to create bimetallic nanoparticles including TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> nanoparticles. Physicochemical and morphological analyses were carried out to validate the formulation’s structure. The obtained characteristics emphasized the presence of a nanostructure involving bimetallic nanoparticles. This formulation exhibited excellent biological activity, including high biocompatibility with Vero and WI38 cells at concentrations of 40.4 and 52 µg/mL, respectively, as well as effective anticancer activity with significant selectivity. The IC50 values were determined to be 19 and 22 µg/mL for MCF7 and A549 cells, respectively. The antimicrobial assessment revealed the highest MIC value for <i>A. niger</i> at 50 µg/mL, while the lowest MIC value was observed for Gram-positive bacteria at 3.12 µg/mL. Additionally, the nanocomposite demonstrated antioxidant activity at a low concentration of 1.5 µg/mL. |
| first_indexed | 2024-03-10T21:09:51Z |
| format | Article |
| id | doaj.art-6c4322802af04e5fbf93f44e27f5413a |
| institution | Directory Open Access Journal |
| issn | 2504-477X |
| language | English |
| last_indexed | 2024-03-10T21:09:51Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Composites Science |
| spelling | doaj.art-6c4322802af04e5fbf93f44e27f5413a2023-11-19T16:55:07ZengMDPI AGJournal of Composites Science2504-477X2023-10-0171042610.3390/jcs7100426New Eco-Friendly, Biocompatible, Bactericidal, Fungicidal and Anticancer-Activity-Exhibiting Nanocomposites Based on Bimetallic TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> Nanoparticle Core and Biopolymer ShellsMohamed S. Hasanin0Yasser Elhenawy1Shereen M. S. Abdel-Hamid2Yasser Fouad3Toderaș Monica4O. A. Al-Qabandi5Miroslawa El Fray6Mohamed Bassyouni7Department of Cellulose and Paper, National Research Centre, Dokki, Cairo 12622, EgyptDepartment of Mechanical Power Engineering, Faculty of Engineering, Port Said University, Port Said 42526, EgyptEgyptian Academy for Engineering and Advanced Technology (EA&EAT) Affiliated to Ministry of Military Production, Department of Chemical Engineering, Km# 3 Cairo-Belbeis Desert Road, Cairo 3066, EgyptDepartment of Applied Mechanical Engineering, College of Applied Engineering, Muzahimiyah Branch, King Saud University, P.O. Box 800, Riyadh 11421, Saudi ArabiaFaculty of Sciences, Oradea University St. No. 1, 410087 Oradea, RomaniaSchool of Engineering and Technology, Chemical Engineering Department, American University of Middle East, 250 St., Block 6, Building 1, Egaila 54200, KuwaitDepartment of Polymer and Biomaterials Science, West Pomeranian University of Technology in Szczecin, Al. Piastow 45, 70-311 Szczecin, PolandCenter of Excellence in Membrane-Based Water Desalination Technology for Testing and Characterization (CEMTC), Port Said University, Port Said 42526, EgyptNanoparticles have attracted substantial attention for their diverse range of applications, particularly in biomedicine applications and drug delivery, owing to their unique properties. However, their tiny size facilitates easy cellular entry, which can also lead to interactions with cellular components, potentially resulting in toxicity and undesirable effects. In this study, a novel nanocomposite formulation was developed using biopolymers, specifically ethylcellulose and collagen, as capping and stabilizing agents to create bimetallic nanoparticles including TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> nanoparticles. Physicochemical and morphological analyses were carried out to validate the formulation’s structure. The obtained characteristics emphasized the presence of a nanostructure involving bimetallic nanoparticles. This formulation exhibited excellent biological activity, including high biocompatibility with Vero and WI38 cells at concentrations of 40.4 and 52 µg/mL, respectively, as well as effective anticancer activity with significant selectivity. The IC50 values were determined to be 19 and 22 µg/mL for MCF7 and A549 cells, respectively. The antimicrobial assessment revealed the highest MIC value for <i>A. niger</i> at 50 µg/mL, while the lowest MIC value was observed for Gram-positive bacteria at 3.12 µg/mL. Additionally, the nanocomposite demonstrated antioxidant activity at a low concentration of 1.5 µg/mL.https://www.mdpi.com/2504-477X/7/10/426nanocompositebiopolymerglycogenethylcellulosebiocompatibilitybimetallic nanoparticles |
| spellingShingle | Mohamed S. Hasanin Yasser Elhenawy Shereen M. S. Abdel-Hamid Yasser Fouad Toderaș Monica O. A. Al-Qabandi Miroslawa El Fray Mohamed Bassyouni New Eco-Friendly, Biocompatible, Bactericidal, Fungicidal and Anticancer-Activity-Exhibiting Nanocomposites Based on Bimetallic TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> Nanoparticle Core and Biopolymer Shells Journal of Composites Science nanocomposite biopolymer glycogen ethylcellulose biocompatibility bimetallic nanoparticles |
| title | New Eco-Friendly, Biocompatible, Bactericidal, Fungicidal and Anticancer-Activity-Exhibiting Nanocomposites Based on Bimetallic TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> Nanoparticle Core and Biopolymer Shells |
| title_full | New Eco-Friendly, Biocompatible, Bactericidal, Fungicidal and Anticancer-Activity-Exhibiting Nanocomposites Based on Bimetallic TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> Nanoparticle Core and Biopolymer Shells |
| title_fullStr | New Eco-Friendly, Biocompatible, Bactericidal, Fungicidal and Anticancer-Activity-Exhibiting Nanocomposites Based on Bimetallic TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> Nanoparticle Core and Biopolymer Shells |
| title_full_unstemmed | New Eco-Friendly, Biocompatible, Bactericidal, Fungicidal and Anticancer-Activity-Exhibiting Nanocomposites Based on Bimetallic TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> Nanoparticle Core and Biopolymer Shells |
| title_short | New Eco-Friendly, Biocompatible, Bactericidal, Fungicidal and Anticancer-Activity-Exhibiting Nanocomposites Based on Bimetallic TiO<sub>2</sub>@Cr<sub>2</sub>O<sub>3</sub> Nanoparticle Core and Biopolymer Shells |
| title_sort | new eco friendly biocompatible bactericidal fungicidal and anticancer activity exhibiting nanocomposites based on bimetallic tio sub 2 sub cr sub 2 sub o sub 3 sub nanoparticle core and biopolymer shells |
| topic | nanocomposite biopolymer glycogen ethylcellulose biocompatibility bimetallic nanoparticles |
| url | https://www.mdpi.com/2504-477X/7/10/426 |
| work_keys_str_mv | AT mohamedshasanin newecofriendlybiocompatiblebactericidalfungicidalandanticanceractivityexhibitingnanocompositesbasedonbimetallictiosub2subcrsub2subosub3subnanoparticlecoreandbiopolymershells AT yasserelhenawy newecofriendlybiocompatiblebactericidalfungicidalandanticanceractivityexhibitingnanocompositesbasedonbimetallictiosub2subcrsub2subosub3subnanoparticlecoreandbiopolymershells AT shereenmsabdelhamid newecofriendlybiocompatiblebactericidalfungicidalandanticanceractivityexhibitingnanocompositesbasedonbimetallictiosub2subcrsub2subosub3subnanoparticlecoreandbiopolymershells AT yasserfouad newecofriendlybiocompatiblebactericidalfungicidalandanticanceractivityexhibitingnanocompositesbasedonbimetallictiosub2subcrsub2subosub3subnanoparticlecoreandbiopolymershells AT toderasmonica newecofriendlybiocompatiblebactericidalfungicidalandanticanceractivityexhibitingnanocompositesbasedonbimetallictiosub2subcrsub2subosub3subnanoparticlecoreandbiopolymershells AT oaalqabandi newecofriendlybiocompatiblebactericidalfungicidalandanticanceractivityexhibitingnanocompositesbasedonbimetallictiosub2subcrsub2subosub3subnanoparticlecoreandbiopolymershells AT miroslawaelfray newecofriendlybiocompatiblebactericidalfungicidalandanticanceractivityexhibitingnanocompositesbasedonbimetallictiosub2subcrsub2subosub3subnanoparticlecoreandbiopolymershells AT mohamedbassyouni newecofriendlybiocompatiblebactericidalfungicidalandanticanceractivityexhibitingnanocompositesbasedonbimetallictiosub2subcrsub2subosub3subnanoparticlecoreandbiopolymershells |