25 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets
Samuel Mbadu Lelo,1,2 François-Pantaléon Musungayi Kajingulu,1,3,4 Jean-Robert Makulo,1,2 Yannick Mayamba Nlandu,1,5 Justine Busanga Bukabau,1,5 Pierre Koso Mbulupasu,1,6 Augustin Luzayadio Longo,1 Jeanine Nina Losa Luse,7 Vieux Momeme Mokoli,1,2 Ernest Kiswaya Sumaili,1 Nazaire Mangani Nseka1 1Hemo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-02-01
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| Series: | International Journal of Nephrology and Renovascular Disease |
| Subjects: | |
| Online Access: | https://www.dovepress.com/25-oh-vitamin-d-and-intact-parathyroid-hormone-in-congolese-hemodialys-peer-reviewed-fulltext-article-IJNRD |
| _version_ | 1797301931404689408 |
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| author | Mbadu Lelo S Musungayi Kajingulu FP Makulo JR Mayamba Nlandu Y Busanga Bukabau J Koso Mbulupasu P Luzayadio Longo A Losa Luse JN Momeme Mokoli V Kiswaya Sumaili E Mangani Nseka N |
| author_facet | Mbadu Lelo S Musungayi Kajingulu FP Makulo JR Mayamba Nlandu Y Busanga Bukabau J Koso Mbulupasu P Luzayadio Longo A Losa Luse JN Momeme Mokoli V Kiswaya Sumaili E Mangani Nseka N |
| author_sort | Mbadu Lelo S |
| collection | DOAJ |
| description | Samuel Mbadu Lelo,1,2 François-Pantaléon Musungayi Kajingulu,1,3,4 Jean-Robert Makulo,1,2 Yannick Mayamba Nlandu,1,5 Justine Busanga Bukabau,1,5 Pierre Koso Mbulupasu,1,6 Augustin Luzayadio Longo,1 Jeanine Nina Losa Luse,7 Vieux Momeme Mokoli,1,2 Ernest Kiswaya Sumaili,1 Nazaire Mangani Nseka1 1Hemodialysis Center, Division of Nephrology, Kinshasa University Hospital, Kinshasa, Democratic Republic of the Congo; 2Hemodialysis Center, Ngaliema Medical Center, Kinshasa, Democratic Republic of the Congo; 3Dialysis Center, HJ Hospital, Kinshasa, Democratic Republic of the Congo; 4Department of Internal Medicine, Saint-Joseph Hospital, Kinshasa, Democratic Republic of the Congo; 5Hemodialysis Center, Centre Médical de Kinshasa, Kinshasa, Democratic Republic of the Congo; 6Department of Internal Medicine, Clinique Ngaliema, Kinshasa, Democratic Republic of the Congo; 7Hemodialysis Center, Hôpital Général de Référence de Kinshasa, Kinshasa, Democratic Republic of the CongoCorrespondence: Jean-Robert Makulo, Email jrmakulo2016@gmail.comBackground: Data on 25 [OH] vitamin D and intact parathyroid hormone [iPTH] in hemodialysis patients are very limited in sub-Saharan African countries. The present study aimed to assess the magnitude of hypovitaminosis D, and to evaluate the achievement of iPTH KDIGO 2017 targets among chronic hemodialysis patients followed in Kinshasa.Methods: We conducted a multicenter cross-sectional study in 6 hospitals in Kinshasa. All patients followed on hemodialysis for more than 3 months were included. Hypovitaminosis D was defined as < 30 ng/mL (insufficiency = 20– 29 ng/mL; deficiency if < 20 ng/mL) and the targets for iPTH values were based on the 2017 KDIGO guidelines. The determinants for hypovitaminosis D were evaluated by logistic regression.Results: 251 patients [mean age 56 ± 14 years, 72.5% men, 63% hypertensive, 31% diabetic, 100% supplemented with native 25 [OH] vitamin D + CaCO3 were included. Hypovitaminosis D was found in 79.7% (deficiency 47.4%) and was associated with the male gender aOR 2.7 [1.4– 5.2], p = 0.004, the low-permeability dialyzer 2.2 [1.1– 4.2], p = 0.025 and anemia 3.9 [1.2– 12.7], p = 0.022. Only 40% of patients with 25 [OH] vitamin D deficiency had iPTH according to KDIGO targets vs 6% of patients with severe hyperparathyroidism (iPTH > 600 pg/mL), 45% with levels between 16 and 150 pg/mL and 9% a iPTH ≤ 15 pg/mL.Conclusion: Despite a sunny environment, a large proportion of Congolese hemodialysis patients have hypovitaminosis D, in particular a deficiency. Among them, less than half have target iPTH values. These results show the benefit of regular monitoring of these parameters in order to optimize treatment.Keywords: KDIGO targets, hemodialysis, hypovitaminosis D, iPTH |
| first_indexed | 2024-03-07T23:29:39Z |
| format | Article |
| id | doaj.art-6c46f669efd9493ea7b7064572acf481 |
| institution | Directory Open Access Journal |
| issn | 1178-7058 |
| language | English |
| last_indexed | 2024-03-07T23:29:39Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nephrology and Renovascular Disease |
| spelling | doaj.art-6c46f669efd9493ea7b7064572acf4812024-02-20T17:10:12ZengDove Medical PressInternational Journal of Nephrology and Renovascular Disease1178-70582024-02-01Volume 1771799057025 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO TargetsMbadu Lelo SMusungayi Kajingulu FPMakulo JRMayamba Nlandu YBusanga Bukabau JKoso Mbulupasu PLuzayadio Longo ALosa Luse JNMomeme Mokoli VKiswaya Sumaili EMangani Nseka NSamuel Mbadu Lelo,1,2 François-Pantaléon Musungayi Kajingulu,1,3,4 Jean-Robert Makulo,1,2 Yannick Mayamba Nlandu,1,5 Justine Busanga Bukabau,1,5 Pierre Koso Mbulupasu,1,6 Augustin Luzayadio Longo,1 Jeanine Nina Losa Luse,7 Vieux Momeme Mokoli,1,2 Ernest Kiswaya Sumaili,1 Nazaire Mangani Nseka1 1Hemodialysis Center, Division of Nephrology, Kinshasa University Hospital, Kinshasa, Democratic Republic of the Congo; 2Hemodialysis Center, Ngaliema Medical Center, Kinshasa, Democratic Republic of the Congo; 3Dialysis Center, HJ Hospital, Kinshasa, Democratic Republic of the Congo; 4Department of Internal Medicine, Saint-Joseph Hospital, Kinshasa, Democratic Republic of the Congo; 5Hemodialysis Center, Centre Médical de Kinshasa, Kinshasa, Democratic Republic of the Congo; 6Department of Internal Medicine, Clinique Ngaliema, Kinshasa, Democratic Republic of the Congo; 7Hemodialysis Center, Hôpital Général de Référence de Kinshasa, Kinshasa, Democratic Republic of the CongoCorrespondence: Jean-Robert Makulo, Email jrmakulo2016@gmail.comBackground: Data on 25 [OH] vitamin D and intact parathyroid hormone [iPTH] in hemodialysis patients are very limited in sub-Saharan African countries. The present study aimed to assess the magnitude of hypovitaminosis D, and to evaluate the achievement of iPTH KDIGO 2017 targets among chronic hemodialysis patients followed in Kinshasa.Methods: We conducted a multicenter cross-sectional study in 6 hospitals in Kinshasa. All patients followed on hemodialysis for more than 3 months were included. Hypovitaminosis D was defined as < 30 ng/mL (insufficiency = 20– 29 ng/mL; deficiency if < 20 ng/mL) and the targets for iPTH values were based on the 2017 KDIGO guidelines. The determinants for hypovitaminosis D were evaluated by logistic regression.Results: 251 patients [mean age 56 ± 14 years, 72.5% men, 63% hypertensive, 31% diabetic, 100% supplemented with native 25 [OH] vitamin D + CaCO3 were included. Hypovitaminosis D was found in 79.7% (deficiency 47.4%) and was associated with the male gender aOR 2.7 [1.4– 5.2], p = 0.004, the low-permeability dialyzer 2.2 [1.1– 4.2], p = 0.025 and anemia 3.9 [1.2– 12.7], p = 0.022. Only 40% of patients with 25 [OH] vitamin D deficiency had iPTH according to KDIGO targets vs 6% of patients with severe hyperparathyroidism (iPTH > 600 pg/mL), 45% with levels between 16 and 150 pg/mL and 9% a iPTH ≤ 15 pg/mL.Conclusion: Despite a sunny environment, a large proportion of Congolese hemodialysis patients have hypovitaminosis D, in particular a deficiency. Among them, less than half have target iPTH values. These results show the benefit of regular monitoring of these parameters in order to optimize treatment.Keywords: KDIGO targets, hemodialysis, hypovitaminosis D, iPTHhttps://www.dovepress.com/25-oh-vitamin-d-and-intact-parathyroid-hormone-in-congolese-hemodialys-peer-reviewed-fulltext-article-IJNRDkdigo targetshemodialysishypovitaminosis dipth. |
| spellingShingle | Mbadu Lelo S Musungayi Kajingulu FP Makulo JR Mayamba Nlandu Y Busanga Bukabau J Koso Mbulupasu P Luzayadio Longo A Losa Luse JN Momeme Mokoli V Kiswaya Sumaili E Mangani Nseka N 25 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets International Journal of Nephrology and Renovascular Disease kdigo targets hemodialysis hypovitaminosis d ipth. |
| title | 25 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets |
| title_full | 25 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets |
| title_fullStr | 25 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets |
| title_full_unstemmed | 25 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets |
| title_short | 25 [OH] Vitamin D and Intact Parathyroid Hormone in Congolese Hemodialysis Patients: Evaluation of KDIGO Targets |
| title_sort | 25 oh vitamin d and intact parathyroid hormone in congolese hemodialysis patients evaluation of kdigo targets |
| topic | kdigo targets hemodialysis hypovitaminosis d ipth. |
| url | https://www.dovepress.com/25-oh-vitamin-d-and-intact-parathyroid-hormone-in-congolese-hemodialys-peer-reviewed-fulltext-article-IJNRD |
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