Increased Temporal Dynamics of Intrinsic Brain Activity in Sensory and Perceptual Network of Schizophrenia
Schizophrenic subject is thought as a self-disorder patient related with abnormal brain functional network. It has been hypothesized that self-disorder is associated with the deficient functional integration of multisensory body signals in schizophrenic subjects. To further verify this assumption, 5...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00484/full |
| _version_ | 1818994709955084288 |
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| author | Youxue Zhang Gang Guo Yuan Tian |
| author_facet | Youxue Zhang Gang Guo Yuan Tian |
| author_sort | Youxue Zhang |
| collection | DOAJ |
| description | Schizophrenic subject is thought as a self-disorder patient related with abnormal brain functional network. It has been hypothesized that self-disorder is associated with the deficient functional integration of multisensory body signals in schizophrenic subjects. To further verify this assumption, 53 chronic schizophrenic subjects and 67 healthy subjects were included in this study and underwent resting-state functional magnetic resonance imaging. The data-driven methods, whole-brain temporal variability of fractional amplitude of low-frequency fluctuations and regional homogeneity (ReHo), were used to investigate dynamic local functional connectivity and dynamic local functional activity changes in schizophrenic subjects. Patients with schizophrenia exhibited increased temporal variability ReHo and fractional amplitude of low-frequency fluctuations across time windows within sensory and perception network (such as occipital gyrus, precentral and postcentral gyri, superior temporal gyrus, and thalamus). Critically, the increased dynamic ReHo of thalamus is significantly correlated with positive and total symptom of schizophrenic subjects. Our findings revealed that deficit in sensory and perception functional networks might contribute to neural physiopathology of self-disorder in schizophrenic subjects. |
| first_indexed | 2024-12-20T21:02:16Z |
| format | Article |
| id | doaj.art-6c487df5e4574c049966429bbdbc238d |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-20T21:02:16Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-6c487df5e4574c049966429bbdbc238d2022-12-21T19:26:40ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-07-011010.3389/fpsyt.2019.00484440537Increased Temporal Dynamics of Intrinsic Brain Activity in Sensory and Perceptual Network of SchizophreniaYouxue Zhang0Gang Guo1Yuan Tian2School of Psychology, Chengdu Normal University, Chengdu, ChinaSchool of Psychology, Chengdu Normal University, Chengdu, ChinaSchool of Foreign Languages, Chengdu Normal University, Chengdu, ChinaSchizophrenic subject is thought as a self-disorder patient related with abnormal brain functional network. It has been hypothesized that self-disorder is associated with the deficient functional integration of multisensory body signals in schizophrenic subjects. To further verify this assumption, 53 chronic schizophrenic subjects and 67 healthy subjects were included in this study and underwent resting-state functional magnetic resonance imaging. The data-driven methods, whole-brain temporal variability of fractional amplitude of low-frequency fluctuations and regional homogeneity (ReHo), were used to investigate dynamic local functional connectivity and dynamic local functional activity changes in schizophrenic subjects. Patients with schizophrenia exhibited increased temporal variability ReHo and fractional amplitude of low-frequency fluctuations across time windows within sensory and perception network (such as occipital gyrus, precentral and postcentral gyri, superior temporal gyrus, and thalamus). Critically, the increased dynamic ReHo of thalamus is significantly correlated with positive and total symptom of schizophrenic subjects. Our findings revealed that deficit in sensory and perception functional networks might contribute to neural physiopathology of self-disorder in schizophrenic subjects.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00484/fullschizophreniafunctional connectivitytemporal variabilityself-disordersensory and perceptual network |
| spellingShingle | Youxue Zhang Gang Guo Yuan Tian Increased Temporal Dynamics of Intrinsic Brain Activity in Sensory and Perceptual Network of Schizophrenia Frontiers in Psychiatry schizophrenia functional connectivity temporal variability self-disorder sensory and perceptual network |
| title | Increased Temporal Dynamics of Intrinsic Brain Activity in Sensory and Perceptual Network of Schizophrenia |
| title_full | Increased Temporal Dynamics of Intrinsic Brain Activity in Sensory and Perceptual Network of Schizophrenia |
| title_fullStr | Increased Temporal Dynamics of Intrinsic Brain Activity in Sensory and Perceptual Network of Schizophrenia |
| title_full_unstemmed | Increased Temporal Dynamics of Intrinsic Brain Activity in Sensory and Perceptual Network of Schizophrenia |
| title_short | Increased Temporal Dynamics of Intrinsic Brain Activity in Sensory and Perceptual Network of Schizophrenia |
| title_sort | increased temporal dynamics of intrinsic brain activity in sensory and perceptual network of schizophrenia |
| topic | schizophrenia functional connectivity temporal variability self-disorder sensory and perceptual network |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00484/full |
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