The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney Transplantation
There are several premises that the body composition of kidney transplant recipients may play a role in tacrolimus metabolism early after transplantation. The present study aimed at analyzing the relationship between the body composition parameters assessed by bioimpedance analysis (BIA) and initial...
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MDPI AG
2021-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/24/5793 |
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| author | Aureliusz Kolonko Patrycja Pokora Natalia Słabiak-Błaż Beata Czerwieńska Henryk Karkoszka Piotr Kuczera Grzegorz Piecha Andrzej Więcek |
| author_facet | Aureliusz Kolonko Patrycja Pokora Natalia Słabiak-Błaż Beata Czerwieńska Henryk Karkoszka Piotr Kuczera Grzegorz Piecha Andrzej Więcek |
| author_sort | Aureliusz Kolonko |
| collection | DOAJ |
| description | There are several premises that the body composition of kidney transplant recipients may play a role in tacrolimus metabolism early after transplantation. The present study aimed at analyzing the relationship between the body composition parameters assessed by bioimpedance analysis (BIA) and initial tacrolimus metabolism. Immediately prior to transplantation, BIA using InBody 770 device was performed in 122 subjects. Tacrolimus concentration-to-dose (C/D) ratio was calculated based on the first blood trough level measurement. There was no difference in phase angle, visceral fat area, lean body mass index (LBMI) and the proportion of lean mass as a percentage of total body mass between the subgroups of slow and fast metabolizers. However, subjects with LBMI ≥ median value of 18.7 kg/m<sup>2</sup>, despite similar initial tacrolimus dose per kg of body weight, were characterized by a significantly lower tacrolimus C/D ratio (median 1.39 vs. 1.67, respectively; <i>p</i> < 0.05) in comparison with the subgroup of lower LBMI. Multivariate regression analysis confirmed that age (r<sub>partial</sub> = 0.322; <i>p</i> < 0.001) and LBMI (r<sub>partial</sub> = −0.254; <i>p</i> < 0.01) independently influenced the tacrolimus C/D ratio. A LBMI assessed by BIA may influence the tacrolimus metabolism in the early post-transplant period and can be a useful in the optimization of initial tacrolimus dosing. |
| first_indexed | 2024-03-10T03:51:41Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:51:41Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6c498dcbf5fc4e1a9fffcc62c45f0ba62023-11-23T08:56:18ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-011024579310.3390/jcm10245793The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney TransplantationAureliusz Kolonko0Patrycja Pokora1Natalia Słabiak-Błaż2Beata Czerwieńska3Henryk Karkoszka4Piotr Kuczera5Grzegorz Piecha6Andrzej Więcek7Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandThere are several premises that the body composition of kidney transplant recipients may play a role in tacrolimus metabolism early after transplantation. The present study aimed at analyzing the relationship between the body composition parameters assessed by bioimpedance analysis (BIA) and initial tacrolimus metabolism. Immediately prior to transplantation, BIA using InBody 770 device was performed in 122 subjects. Tacrolimus concentration-to-dose (C/D) ratio was calculated based on the first blood trough level measurement. There was no difference in phase angle, visceral fat area, lean body mass index (LBMI) and the proportion of lean mass as a percentage of total body mass between the subgroups of slow and fast metabolizers. However, subjects with LBMI ≥ median value of 18.7 kg/m<sup>2</sup>, despite similar initial tacrolimus dose per kg of body weight, were characterized by a significantly lower tacrolimus C/D ratio (median 1.39 vs. 1.67, respectively; <i>p</i> < 0.05) in comparison with the subgroup of lower LBMI. Multivariate regression analysis confirmed that age (r<sub>partial</sub> = 0.322; <i>p</i> < 0.001) and LBMI (r<sub>partial</sub> = −0.254; <i>p</i> < 0.01) independently influenced the tacrolimus C/D ratio. A LBMI assessed by BIA may influence the tacrolimus metabolism in the early post-transplant period and can be a useful in the optimization of initial tacrolimus dosing.https://www.mdpi.com/2077-0383/10/24/5793bioimpedance analysisdrug dosinglean body mass indexpharmacokineticstacrolimus C/D ratio |
| spellingShingle | Aureliusz Kolonko Patrycja Pokora Natalia Słabiak-Błaż Beata Czerwieńska Henryk Karkoszka Piotr Kuczera Grzegorz Piecha Andrzej Więcek The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney Transplantation Journal of Clinical Medicine bioimpedance analysis drug dosing lean body mass index pharmacokinetics tacrolimus C/D ratio |
| title | The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney Transplantation |
| title_full | The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney Transplantation |
| title_fullStr | The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney Transplantation |
| title_full_unstemmed | The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney Transplantation |
| title_short | The Relationship between Initial Tacrolimus Metabolism Rate and Recipients Body Composition in Kidney Transplantation |
| title_sort | relationship between initial tacrolimus metabolism rate and recipients body composition in kidney transplantation |
| topic | bioimpedance analysis drug dosing lean body mass index pharmacokinetics tacrolimus C/D ratio |
| url | https://www.mdpi.com/2077-0383/10/24/5793 |
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