Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps
Abstract Background Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps. Methods Inpatients ad...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-05111-z |
| _version_ | 1797199194446888960 |
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| author | Xiaojuan Li Mengting Hu Zhangjun Wang Mei Liu Ying Chen |
| author_facet | Xiaojuan Li Mengting Hu Zhangjun Wang Mei Liu Ying Chen |
| author_sort | Xiaojuan Li |
| collection | DOAJ |
| description | Abstract Background Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps. Methods Inpatients admitted from January 2018 to May 2023 were screened through the hospital information system. Polyps were classified according to pathological morphology. The prevalence of polyps was described by frequency and 95% confidence interval. Univariate and multivariate logistic regression analyses were used to explore the risk factors for CCS and neoplastic polyps. Results In total, 2329 individuals with 3550 polyps were recruited. Among all patients, 76.99% had neoplastic polyps and 44.31% had advanced adenomas. Tubular adenoma had the highest prevalence at 60.15%, and the prevalence of CCS was 3.86%. Patients with a colorectal polyp diameter ≥ 1.0 cm or number ≥ 3 were 8.07 times or 1.98 times more likely to develop CCS than were those with a diameter < 1.0 cm or number < 3, respectively (OR 8.07, 95%CI 4.48–14.55, p < 0.0001; and OR 1.98, 95%CI 1.27–3.09, p = 0.002). The risk of CCS with schistosome egg deposition was also significantly increased (OR 2.70, 95%CI 1.05–6.98). The higher the levels of carbohydrate antigen (CA) 724 (OR 1.01, 95%CI 1.00–1.02) and CA211 (OR 1.16, 95%CI 1.03–1.32) in patients with colorectal polyps were, the greater the risk of CCS. When colorectal neoplastic polyps were analyzed, we discovered that for each 1-year increase in age, the risk of neoplastic polyps increased by 3% (OR 1.03, 95%CI 1.02–1.04), p < 0.0001. Patients with a polyp diameter ≥ 1.0 cm had a 2.11-fold greater risk of neoplastic polyps compared to diameter < 1.0 cm patients (OR 3.11, 95%CI 2.48–3.92), p < 0.0001. In addition, multiple polyps and CA199 levels are risk factors for neoplastic polyps. Conclusion More than 3/4 of colorectal polyp patients have neoplastic polyps. Patients are more inclined to develop CCS and neoplastic polyps if they have large polyps (> 1.0 cm) or multifocal polyps. The levels of the tumor markers CA724 and CA211 show some potential usefulness for predicting CCS and may be exploited for early identification of high-risk populations. |
| first_indexed | 2024-04-24T07:11:53Z |
| format | Article |
| id | doaj.art-6c4a4906c490437ab913f0097d1581ca |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-24T07:11:53Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-6c4a4906c490437ab913f0097d1581ca2024-04-21T11:28:29ZengBMCJournal of Translational Medicine1479-58762024-04-0122111010.1186/s12967-024-05111-zPrevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polypsXiaojuan Li0Mengting Hu1Zhangjun Wang2Mei Liu3Ying Chen4Department of Gastroenterology, Minhang Hospital, Fudan UniversityDepartment of General Medicine, Minhang Hospital, Fudan UniversityProprietary Trading Department, Huaan Securities Co., LtdDepartment of General Medicine, Minhang Hospital, Fudan UniversityDepartment of Gastroenterology, Minhang Hospital, Fudan UniversityAbstract Background Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps. Methods Inpatients admitted from January 2018 to May 2023 were screened through the hospital information system. Polyps were classified according to pathological morphology. The prevalence of polyps was described by frequency and 95% confidence interval. Univariate and multivariate logistic regression analyses were used to explore the risk factors for CCS and neoplastic polyps. Results In total, 2329 individuals with 3550 polyps were recruited. Among all patients, 76.99% had neoplastic polyps and 44.31% had advanced adenomas. Tubular adenoma had the highest prevalence at 60.15%, and the prevalence of CCS was 3.86%. Patients with a colorectal polyp diameter ≥ 1.0 cm or number ≥ 3 were 8.07 times or 1.98 times more likely to develop CCS than were those with a diameter < 1.0 cm or number < 3, respectively (OR 8.07, 95%CI 4.48–14.55, p < 0.0001; and OR 1.98, 95%CI 1.27–3.09, p = 0.002). The risk of CCS with schistosome egg deposition was also significantly increased (OR 2.70, 95%CI 1.05–6.98). The higher the levels of carbohydrate antigen (CA) 724 (OR 1.01, 95%CI 1.00–1.02) and CA211 (OR 1.16, 95%CI 1.03–1.32) in patients with colorectal polyps were, the greater the risk of CCS. When colorectal neoplastic polyps were analyzed, we discovered that for each 1-year increase in age, the risk of neoplastic polyps increased by 3% (OR 1.03, 95%CI 1.02–1.04), p < 0.0001. Patients with a polyp diameter ≥ 1.0 cm had a 2.11-fold greater risk of neoplastic polyps compared to diameter < 1.0 cm patients (OR 3.11, 95%CI 2.48–3.92), p < 0.0001. In addition, multiple polyps and CA199 levels are risk factors for neoplastic polyps. Conclusion More than 3/4 of colorectal polyp patients have neoplastic polyps. Patients are more inclined to develop CCS and neoplastic polyps if they have large polyps (> 1.0 cm) or multifocal polyps. The levels of the tumor markers CA724 and CA211 show some potential usefulness for predicting CCS and may be exploited for early identification of high-risk populations.https://doi.org/10.1186/s12967-024-05111-zPrevalenceColorectal polypsNeoplastic polypsColorectal carcinoma in situTumor markers |
| spellingShingle | Xiaojuan Li Mengting Hu Zhangjun Wang Mei Liu Ying Chen Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps Journal of Translational Medicine Prevalence Colorectal polyps Neoplastic polyps Colorectal carcinoma in situ Tumor markers |
| title | Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps |
| title_full | Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps |
| title_fullStr | Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps |
| title_full_unstemmed | Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps |
| title_short | Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps |
| title_sort | prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps |
| topic | Prevalence Colorectal polyps Neoplastic polyps Colorectal carcinoma in situ Tumor markers |
| url | https://doi.org/10.1186/s12967-024-05111-z |
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