Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age.
Resveratrol (RVTL) is a flavonoid found in red wine and has been publicized heavily as an anti-aging compound. Indeed, basic research confirms that although there is much hype in the promotion of RVTL, flavonoids such as RVTL have a wide range of biological effects. We here investigated the effects...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4690610?pdf=render |
| _version_ | 1817983231070306304 |
|---|---|
| author | Mario Torres-Pérez Ruth Ivonne Tellez-Ballesteros Leonardo Ortiz-López Muhammad Ichwan Nelly Maritza Vega-Rivera Mario Castro-García Ariadna Gómez-Sánchez Gerd Kempermann Gerardo Bernabe Ramirez-Rodriguez |
| author_facet | Mario Torres-Pérez Ruth Ivonne Tellez-Ballesteros Leonardo Ortiz-López Muhammad Ichwan Nelly Maritza Vega-Rivera Mario Castro-García Ariadna Gómez-Sánchez Gerd Kempermann Gerardo Bernabe Ramirez-Rodriguez |
| author_sort | Mario Torres-Pérez |
| collection | DOAJ |
| description | Resveratrol (RVTL) is a flavonoid found in red wine and has been publicized heavily as an anti-aging compound. Indeed, basic research confirms that although there is much hype in the promotion of RVTL, flavonoids such as RVTL have a wide range of biological effects. We here investigated the effects of RVTL treatment on hippocampal plasticity and memory performance in female Balb/C mice, a strain with low baseline levels of adult neurogenesis. Two weeks of treatment with RVTL (40 mg/kg) induced the production of new neurons in vivo by increasing cell survival and possibly precursor cell proliferation. In addition, RVTL decreased the number of apoptotic cells. The number of doublecortin (DCX)-expressing intermediate cells was increased. RVTL stimulated neuronal differentiation in vitro without effects on proliferation. In the dentate gyrus, RVTL promoted the formation and maturation of spines on granule cell dendrites. RVTL also improved performance in the step down passive avoidance test. The RVTL-treated mice showed increase in the levels of two key signaling proteins, phospho-Akt and phospho-PKC, suggesting the involvement of these signaling pathways. Our results support the vision that flavonoids such as resveratrol deserve further examination as plasticity-inducing compounds in the context of successful cognitive aging. |
| first_indexed | 2024-04-13T23:30:38Z |
| format | Article |
| id | doaj.art-6c4a9b137a1e47f895a5a648a0b3ae46 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T23:30:38Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6c4a9b137a1e47f895a5a648a0b3ae462022-12-22T02:24:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014568710.1371/journal.pone.0145687Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age.Mario Torres-PérezRuth Ivonne Tellez-BallesterosLeonardo Ortiz-LópezMuhammad IchwanNelly Maritza Vega-RiveraMario Castro-GarcíaAriadna Gómez-SánchezGerd KempermannGerardo Bernabe Ramirez-RodriguezResveratrol (RVTL) is a flavonoid found in red wine and has been publicized heavily as an anti-aging compound. Indeed, basic research confirms that although there is much hype in the promotion of RVTL, flavonoids such as RVTL have a wide range of biological effects. We here investigated the effects of RVTL treatment on hippocampal plasticity and memory performance in female Balb/C mice, a strain with low baseline levels of adult neurogenesis. Two weeks of treatment with RVTL (40 mg/kg) induced the production of new neurons in vivo by increasing cell survival and possibly precursor cell proliferation. In addition, RVTL decreased the number of apoptotic cells. The number of doublecortin (DCX)-expressing intermediate cells was increased. RVTL stimulated neuronal differentiation in vitro without effects on proliferation. In the dentate gyrus, RVTL promoted the formation and maturation of spines on granule cell dendrites. RVTL also improved performance in the step down passive avoidance test. The RVTL-treated mice showed increase in the levels of two key signaling proteins, phospho-Akt and phospho-PKC, suggesting the involvement of these signaling pathways. Our results support the vision that flavonoids such as resveratrol deserve further examination as plasticity-inducing compounds in the context of successful cognitive aging.http://europepmc.org/articles/PMC4690610?pdf=render |
| spellingShingle | Mario Torres-Pérez Ruth Ivonne Tellez-Ballesteros Leonardo Ortiz-López Muhammad Ichwan Nelly Maritza Vega-Rivera Mario Castro-García Ariadna Gómez-Sánchez Gerd Kempermann Gerardo Bernabe Ramirez-Rodriguez Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age. PLoS ONE |
| title | Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age. |
| title_full | Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age. |
| title_fullStr | Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age. |
| title_full_unstemmed | Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age. |
| title_short | Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age. |
| title_sort | resveratrol enhances neuroplastic changes including hippocampal neurogenesis and memory in balb c mice at six months of age |
| url | http://europepmc.org/articles/PMC4690610?pdf=render |
| work_keys_str_mv | AT mariotorresperez resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage AT ruthivonnetellezballesteros resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage AT leonardoortizlopez resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage AT muhammadichwan resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage AT nellymaritzavegarivera resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage AT mariocastrogarcia resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage AT ariadnagomezsanchez resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage AT gerdkempermann resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage AT gerardobernaberamirezrodriguez resveratrolenhancesneuroplasticchangesincludinghippocampalneurogenesisandmemoryinbalbcmiceatsixmonthsofage |