‘Educated’ Osteoblasts Reduce Osteoclastogenesis in a Bone-Tumor Mimetic Microenvironment

‘Educated’ Osteoblasts Reduce Osteoclastogenesis in a Bone-Tumor Mimetic Microenvironment

Breast cancer (BC) metastases to bone disrupt the balance between osteoblasts and osteoclasts, leading to excessive bone resorption. We identified a novel subpopulation of osteoblasts with tumor-inhibitory properties, called educated osteoblasts (EOs). Here we sought to examine the effect of EOs on...

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Bibliographic Details
Main Authors: Alexus D. Kolb, Jinlu Dai, Evan T. Keller, Karen M. Bussard
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
osteoclast
osteoblast
breast cancer
metastasis
bone
osteoclastogenesis
Online Access:https://www.mdpi.com/2072-6694/13/2/263

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