The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease
Abstract Introduction Degeneration changes of the basal forebrain (BF) are suggested to play an important role in cognitive impairment and memory loss in patients with Alzheimer's disease and Parkinson's disease. However, little is known about if and how the structure and function of BF ar...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2239 |
| _version_ | 1827877387730157568 |
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| author | Yutong Wu Sheng Hu Yi Wang Ting Dong Hongli Wu Yumei Zhang Qianqian Qu Anqin Wang Yinfeng Yang Chuanfu Li Hongxing Kan |
| author_facet | Yutong Wu Sheng Hu Yi Wang Ting Dong Hongli Wu Yumei Zhang Qianqian Qu Anqin Wang Yinfeng Yang Chuanfu Li Hongxing Kan |
| author_sort | Yutong Wu |
| collection | DOAJ |
| description | Abstract Introduction Degeneration changes of the basal forebrain (BF) are suggested to play an important role in cognitive impairment and memory loss in patients with Alzheimer's disease and Parkinson's disease. However, little is known about if and how the structure and function of BF are abnormal in Wilson's disease (WD). Methods Here, we employed the structural and resting‐state functional magnetic resonance imaging (fMRI) data from 19 WD individuals and 24 healthy controls (HC). Voxel‐based morphometry (VBM) and functional connectivity analysis were applied to investigate the structural and functional degeneration changes of BF in WD. Moreover, the linear regression analyses were performed in the patient group to depict the correlations between the aberrant gray volume and functional connectivity of the BF and clinical performances, such as the prospective memory (PM) and mini‐mental state examination (MMSE). Results VBM analysis showed that compared with HC, the volume of overlapping cell groups of BF termed CH1–3 and CH4 was significantly reduced in WD. Additionally, the decreased functional connectivity of the CH4 was distributed in the bilateral temporal‐parietal junction (TPJ), right thalamus, orbitofrontal gyrus (ORB), and left middle cingulate cortex (MCC). The performances of the time‐based prospective memory (TBPM) and event‐based prospective memory (EBPM) were related to reduced functional connectivity between CH4 and right ORB. Besides, the functional connectivity of left TPJ was also significantly correlated with EBPM in WD. Conclusion These findings indicated that the degenerative changes of BF may affect PM through the innervation brain function and may help to understand the neural mechanisms underlying cognitive impairment in WD. |
| first_indexed | 2024-03-12T17:36:44Z |
| format | Article |
| id | doaj.art-6c4cdd07060549889882082e3e12ee1b |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:36:44Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-6c4cdd07060549889882082e3e12ee1b2023-08-04T10:56:25ZengWileyBrain and Behavior2162-32792021-08-01118n/an/a10.1002/brb3.2239The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's diseaseYutong Wu0Sheng Hu1Yi Wang2Ting Dong3Hongli Wu4Yumei Zhang5Qianqian Qu6Anqin Wang7Yinfeng Yang8Chuanfu Li9Hongxing Kan10School of Medical Information Engineering Anhui University of Chinese Medicine Hefei Anhui ChinaSchool of Medical Information Engineering Anhui University of Chinese Medicine Hefei Anhui ChinaSchool of Medical Information Engineering Anhui University of Chinese Medicine Hefei Anhui ChinaMedical Imaging Center The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei Anhui ChinaSchool of Medical Information Engineering Anhui University of Chinese Medicine Hefei Anhui ChinaSchool of Medical Information Engineering Anhui University of Chinese Medicine Hefei Anhui ChinaSchool of Medical Information Engineering Anhui University of Chinese Medicine Hefei Anhui ChinaMedical Imaging Center The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei Anhui ChinaSchool of Medical Information Engineering Anhui University of Chinese Medicine Hefei Anhui ChinaMedical Imaging Center The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei Anhui ChinaSchool of Medical Information Engineering Anhui University of Chinese Medicine Hefei Anhui ChinaAbstract Introduction Degeneration changes of the basal forebrain (BF) are suggested to play an important role in cognitive impairment and memory loss in patients with Alzheimer's disease and Parkinson's disease. However, little is known about if and how the structure and function of BF are abnormal in Wilson's disease (WD). Methods Here, we employed the structural and resting‐state functional magnetic resonance imaging (fMRI) data from 19 WD individuals and 24 healthy controls (HC). Voxel‐based morphometry (VBM) and functional connectivity analysis were applied to investigate the structural and functional degeneration changes of BF in WD. Moreover, the linear regression analyses were performed in the patient group to depict the correlations between the aberrant gray volume and functional connectivity of the BF and clinical performances, such as the prospective memory (PM) and mini‐mental state examination (MMSE). Results VBM analysis showed that compared with HC, the volume of overlapping cell groups of BF termed CH1–3 and CH4 was significantly reduced in WD. Additionally, the decreased functional connectivity of the CH4 was distributed in the bilateral temporal‐parietal junction (TPJ), right thalamus, orbitofrontal gyrus (ORB), and left middle cingulate cortex (MCC). The performances of the time‐based prospective memory (TBPM) and event‐based prospective memory (EBPM) were related to reduced functional connectivity between CH4 and right ORB. Besides, the functional connectivity of left TPJ was also significantly correlated with EBPM in WD. Conclusion These findings indicated that the degenerative changes of BF may affect PM through the innervation brain function and may help to understand the neural mechanisms underlying cognitive impairment in WD.https://doi.org/10.1002/brb3.2239basal forebrainfunctional connectivityfunctional magnetic resonance imagingprospective memoryvoxel‐based morphometryWilson's disease |
| spellingShingle | Yutong Wu Sheng Hu Yi Wang Ting Dong Hongli Wu Yumei Zhang Qianqian Qu Anqin Wang Yinfeng Yang Chuanfu Li Hongxing Kan The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease Brain and Behavior basal forebrain functional connectivity functional magnetic resonance imaging prospective memory voxel‐based morphometry Wilson's disease |
| title | The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease |
| title_full | The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease |
| title_fullStr | The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease |
| title_full_unstemmed | The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease |
| title_short | The degeneration changes of basal forebrain are associated with prospective memory impairment in patients with Wilson's disease |
| title_sort | degeneration changes of basal forebrain are associated with prospective memory impairment in patients with wilson s disease |
| topic | basal forebrain functional connectivity functional magnetic resonance imaging prospective memory voxel‐based morphometry Wilson's disease |
| url | https://doi.org/10.1002/brb3.2239 |
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