Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

Supramolecular signaling assemblies are of interest for their unique signaling properties. A µm scale signaling assembly, the central supramolecular signaling cluster (cSMAC), forms at the center of the interface of T cells activated by antigen-presenting cells. We have determined that it is compose...

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Bibliographic Details
Main Authors: Danielle J Clark, Laura E McMillan, Sin Lih Tan, Gaia Bellomo, Clementine Massoue, Harry Thompson, Lidiya Mykhaylechko, Dominic Alibhai, Xiongtao Ruan, Kentner L Singleton, Minna Du, Alan Hedges, Pamela L Schwartzberg, Paul Verkade, Robert F Murphy, Christoph Wülfing
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
T lymphocytes
supramolecular protein complex
signal transduction
imaging
Online Access:https://elifesciences.org/articles/45789

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