<i>Gardenia jasminoides</i> Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin Production
Allergic rhinitis (AR) is a chronic inflammatory condition affecting the nasal mucosa of the upper airways. Herein, we investigated the effects of extracts from <i>Gardenia jasminoides</i> (GJ), a traditional herbal medicine with anti-inflammatory properties, on AR-associated inflammator...
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| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/10/986 |
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| author | Bo-Jeong Pyun Joo Young Lee Yu Jin Kim Kon-Young Ji Dong Ho Jung Ki-Sun Park Kyuhyung Jo Susanna Choi Myung-A Jung Yun Hee Kim Taesoo Kim |
| author_facet | Bo-Jeong Pyun Joo Young Lee Yu Jin Kim Kon-Young Ji Dong Ho Jung Ki-Sun Park Kyuhyung Jo Susanna Choi Myung-A Jung Yun Hee Kim Taesoo Kim |
| author_sort | Bo-Jeong Pyun |
| collection | DOAJ |
| description | Allergic rhinitis (AR) is a chronic inflammatory condition affecting the nasal mucosa of the upper airways. Herein, we investigated the effects of extracts from <i>Gardenia jasminoides</i> (GJ), a traditional herbal medicine with anti-inflammatory properties, on AR-associated inflammatory responses that cause epithelial damage. We investigated the inhibitory effects of water- and ethanol-extracted GJ (GJW and GJE, respectively) in an ovalbumin-induced AR mouse model and in splenocytes, differentiated Th2 cells, and primary human nasal epithelial cells (HNEpCs). Administering GJW and GJE to ovalbumin-induced AR mice improved clinical symptoms including behavior (sneezing and rubbing), serum cytokine levels, immune cell counts, and histopathological marker levels. Treatment with GJW and GJE reduced the secretion of Th2 cytokines in Th2 cells isolated and differentiated from the splenocytes of these mice. To investigate the underlying molecular mechanisms of AR, we treated IL-4/IL-13-stimulated HNEpCs with GJW and GJE; we found that these extracts significantly reduced the production of mitochondrial reactive oxygen species via the uncoupling protein-2 and periostin, a biomarker of the Th2 inflammatory response. Our results suggest that GJ extracts may potentially serve as therapeutic agents to improve the symptoms of AR by regulating the Th2 inflammatory response of the nasal epithelium. |
| first_indexed | 2024-03-10T06:17:14Z |
| format | Article |
| id | doaj.art-6c4f955f641541ce9c58d1c204284a88 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T06:17:14Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-6c4f955f641541ce9c58d1c204284a882023-11-22T19:35:35ZengMDPI AGPharmaceuticals1424-82472021-09-01141098610.3390/ph14100986<i>Gardenia jasminoides</i> Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin ProductionBo-Jeong Pyun0Joo Young Lee1Yu Jin Kim2Kon-Young Ji3Dong Ho Jung4Ki-Sun Park5Kyuhyung Jo6Susanna Choi7Myung-A Jung8Yun Hee Kim9Taesoo Kim10KM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Science Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaAllergic rhinitis (AR) is a chronic inflammatory condition affecting the nasal mucosa of the upper airways. Herein, we investigated the effects of extracts from <i>Gardenia jasminoides</i> (GJ), a traditional herbal medicine with anti-inflammatory properties, on AR-associated inflammatory responses that cause epithelial damage. We investigated the inhibitory effects of water- and ethanol-extracted GJ (GJW and GJE, respectively) in an ovalbumin-induced AR mouse model and in splenocytes, differentiated Th2 cells, and primary human nasal epithelial cells (HNEpCs). Administering GJW and GJE to ovalbumin-induced AR mice improved clinical symptoms including behavior (sneezing and rubbing), serum cytokine levels, immune cell counts, and histopathological marker levels. Treatment with GJW and GJE reduced the secretion of Th2 cytokines in Th2 cells isolated and differentiated from the splenocytes of these mice. To investigate the underlying molecular mechanisms of AR, we treated IL-4/IL-13-stimulated HNEpCs with GJW and GJE; we found that these extracts significantly reduced the production of mitochondrial reactive oxygen species via the uncoupling protein-2 and periostin, a biomarker of the Th2 inflammatory response. Our results suggest that GJ extracts may potentially serve as therapeutic agents to improve the symptoms of AR by regulating the Th2 inflammatory response of the nasal epithelium.https://www.mdpi.com/1424-8247/14/10/986allergic rhinitisinflammation<i>Gardenia jasminoides</i>reactive oxygen speciescytokinesT-helper type 2 cell |
| spellingShingle | Bo-Jeong Pyun Joo Young Lee Yu Jin Kim Kon-Young Ji Dong Ho Jung Ki-Sun Park Kyuhyung Jo Susanna Choi Myung-A Jung Yun Hee Kim Taesoo Kim <i>Gardenia jasminoides</i> Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin Production Pharmaceuticals allergic rhinitis inflammation <i>Gardenia jasminoides</i> reactive oxygen species cytokines T-helper type 2 cell |
| title | <i>Gardenia jasminoides</i> Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin Production |
| title_full | <i>Gardenia jasminoides</i> Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin Production |
| title_fullStr | <i>Gardenia jasminoides</i> Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin Production |
| title_full_unstemmed | <i>Gardenia jasminoides</i> Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin Production |
| title_short | <i>Gardenia jasminoides</i> Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin Production |
| title_sort | i gardenia jasminoides i attenuates allergic rhinitis induced inflammation by inhibiting periostin production |
| topic | allergic rhinitis inflammation <i>Gardenia jasminoides</i> reactive oxygen species cytokines T-helper type 2 cell |
| url | https://www.mdpi.com/1424-8247/14/10/986 |
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