Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis
Epidemiological evidence finds cigarette smoking is a common risk factor for a number of diseases, not only in the lung but also in other tissues, such as the gastrointestinal tract. While it is well-documented that smoking directly drives lung inflammatory disease, how it promotes disease in periph...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00075/full |
| _version_ | 1818530171636940800 |
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| author | Myunghoo Kim Bonhee Gu Matthew C. Madison Hyo Won Song Kendra Norwood Andrea A. Hill Wan-Jung Wu David Corry David Corry David Corry David Corry David Corry Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Gretchen E. Diehl Gretchen E. Diehl Gretchen E. Diehl |
| author_facet | Myunghoo Kim Bonhee Gu Matthew C. Madison Hyo Won Song Kendra Norwood Andrea A. Hill Wan-Jung Wu David Corry David Corry David Corry David Corry David Corry Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Gretchen E. Diehl Gretchen E. Diehl Gretchen E. Diehl |
| author_sort | Myunghoo Kim |
| collection | DOAJ |
| description | Epidemiological evidence finds cigarette smoking is a common risk factor for a number of diseases, not only in the lung but also in other tissues, such as the gastrointestinal tract. While it is well-documented that smoking directly drives lung inflammatory disease, how it promotes disease in peripheral tissues is incompletely understood. In this study, we utilized a mouse model of short-term smoke exposure and found increased Th17 cells and neutrophilia in the lung as well as in the circulation. Following intestinal inflammatory challenge, smoke exposed mice showed increased pathology which corresponds to enhanced intestinal Th17 cells, ILC3 and neutrophils within intestinal tissue. Using cellular depletion and genetic deficiencies, we define a cellular loop by which IL-17A and downstream neutrophils drive cigarette smoke-enhanced intestinal inflammation. Collectively, cigarette smoke induced local lung Th17 responses lead to increased systemic susceptibility to inflammatory insult through enhanced circulating neutrophils. These data demonstrate a cellular pathway by which inflammatory challenge in the lung can sensitize the intestine to enhanced pathological innate and adaptive immune responses. |
| first_indexed | 2024-12-11T17:16:20Z |
| format | Article |
| id | doaj.art-6c4fa8ec446a40ff82ed77fa3e1a721a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T17:16:20Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6c4fa8ec446a40ff82ed77fa3e1a721a2022-12-22T00:57:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-01-011010.3389/fimmu.2019.00075420401Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil AxisMyunghoo Kim0Bonhee Gu1Matthew C. Madison2Hyo Won Song3Kendra Norwood4Andrea A. Hill5Wan-Jung Wu6David Corry7David Corry8David Corry9David Corry10David Corry11Farrah Kheradmand12Farrah Kheradmand13Farrah Kheradmand14Farrah Kheradmand15Farrah Kheradmand16Gretchen E. Diehl17Gretchen E. Diehl18Gretchen E. Diehl19Department of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, United StatesDepartments of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United StatesDepartments of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United StatesDepartment of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, United StatesDepartment of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, United StatesDepartment of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, United StatesDepartment of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, United StatesDepartments of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United StatesBiology of Inflammation Center, Baylor College of Medicine, Houston, TX, United StatesDepartment of Medicine, Pulmonary and Critical Care, Baylor College of Medicine, Houston, TX, United StatesThe Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United StatesCenter for Translational Research in Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United StatesDepartments of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United StatesBiology of Inflammation Center, Baylor College of Medicine, Houston, TX, United StatesDepartment of Medicine, Pulmonary and Critical Care, Baylor College of Medicine, Houston, TX, United StatesThe Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United StatesCenter for Translational Research in Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, United StatesDepartment of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, United StatesBiology of Inflammation Center, Baylor College of Medicine, Houston, TX, United StatesThe Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United StatesEpidemiological evidence finds cigarette smoking is a common risk factor for a number of diseases, not only in the lung but also in other tissues, such as the gastrointestinal tract. While it is well-documented that smoking directly drives lung inflammatory disease, how it promotes disease in peripheral tissues is incompletely understood. In this study, we utilized a mouse model of short-term smoke exposure and found increased Th17 cells and neutrophilia in the lung as well as in the circulation. Following intestinal inflammatory challenge, smoke exposed mice showed increased pathology which corresponds to enhanced intestinal Th17 cells, ILC3 and neutrophils within intestinal tissue. Using cellular depletion and genetic deficiencies, we define a cellular loop by which IL-17A and downstream neutrophils drive cigarette smoke-enhanced intestinal inflammation. Collectively, cigarette smoke induced local lung Th17 responses lead to increased systemic susceptibility to inflammatory insult through enhanced circulating neutrophils. These data demonstrate a cellular pathway by which inflammatory challenge in the lung can sensitize the intestine to enhanced pathological innate and adaptive immune responses.https://www.frontiersin.org/article/10.3389/fimmu.2019.00075/fullcigarette smokeintestinal inflammationTh17 cellsneutrophilslung-gut axis |
| spellingShingle | Myunghoo Kim Bonhee Gu Matthew C. Madison Hyo Won Song Kendra Norwood Andrea A. Hill Wan-Jung Wu David Corry David Corry David Corry David Corry David Corry Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Farrah Kheradmand Gretchen E. Diehl Gretchen E. Diehl Gretchen E. Diehl Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis Frontiers in Immunology cigarette smoke intestinal inflammation Th17 cells neutrophils lung-gut axis |
| title | Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis |
| title_full | Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis |
| title_fullStr | Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis |
| title_full_unstemmed | Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis |
| title_short | Cigarette Smoke Induces Intestinal Inflammation via a Th17 Cell-Neutrophil Axis |
| title_sort | cigarette smoke induces intestinal inflammation via a th17 cell neutrophil axis |
| topic | cigarette smoke intestinal inflammation Th17 cells neutrophils lung-gut axis |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00075/full |
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